Talk Python To Me

• #522: Data Sci Tips and Tricks from CodeCut.ai

  Today we’re turning tiny tips into big wins. Khuyen Tran, creator of CodeCut.ai, has shipped hundreds of bite-size Python and data science snippets across four years. We dig into open-source tools you can use right now, cleaner workflows, and why notebooks and scripts don’t have to be enemies. If you want faster insights with fewer yak-shaves, this one’s packed with takeaways you can apply before lunch. Let’s get into it. Episode sponsors Sentry Error Monitoring, Code TALKPYTHON Agntcy Talk Python Courses Links from the show Khuyen Tran (LinkedIn): linkedin.com Khuyen Tran (GitHub): github.com CodeCut: codecut.ai Production-ready Data Science Book (discount code TalkPython): codecut.ai Why UV Might Be All You Need: codecut.ai How to Structure a Data Science Project for Readability and Transparency: codecut.ai Stop Hard-coding: Use Configuration Files Instead: codecut.ai Simplify Your Python Logging with Loguru: codecut.ai Git for Data Scientists: Learn Git Through Practical Examples: codecut.ai Marimo (A Modern Notebook for Reproducible Data Science): codecut.ai Text Similarity & Fuzzy Matching Guide: codecut.ai Loguru (Python logging made simple): github.com Hydra: hydra.cc Marimo: marimo.io Quarto: quarto.org Show Your Work! Book: austinkleon.com Watch this episode on YouTube: youtube.com Episode #522 deep-dive: talkpython.fm/522 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @[email protected] X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @[email protected] Michael on X.com: @mkennedy

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• #521: Red Teaming LLMs and GenAI with PyRIT

  English is now an API. Our apps read untrusted text; they follow instructions hidden in plain sight, and sometimes they turn that text into action. If you connect a model to tools or let it read documents from the wild, you have created a brand new attack surface. In this episode, we will make that concrete. We will talk about the attacks teams are seeing in 2025, the defenses that actually work, and how to test those defenses the same way we test code. Our guides are Tori Westerhoff and Roman Lutz from Microsoft. They help lead AI red teaming and build PyRIT, a Python framework the Microsoft AI Red Team uses to pressure test real products. By the end of this hour you will know where the biggest risks live, what you can ship this quarter to reduce them, and how PyRIT can turn security from a one time audit into an everyday engineering practice. Episode sponsors Sentry AI Monitoring, Code TALKPYTHON Agntcy Talk Python Courses Links from the show Tori Westerhoff: linkedin.com Roman Lutz: linkedin.com PyRIT: aka.ms/pyrit Microsoft AI Red Team page: learn.microsoft.com 2025 Top 10 Risk & Mitigations for LLMs and Gen AI Apps: genai.owasp.org AI Red Teaming Agent: learn.microsoft.com 3 takeaways from red teaming 100 generative AI products: microsoft.com MIT report: 95% of generative AI pilots at companies are failing: fortune.com A couple of "Little Bobby AI" cartoons Give me candy: talkpython.fm Tell me a joke: talkpython.fm Watch this episode on YouTube: youtube.com Episode #521 deep-dive: talkpython.fm/521 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @[email protected] X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @[email protected] Michael on X.com: @mkennedy

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• #520: pyx - the other side of the uv coin (announcing pyx)

  A couple years ago, Charlie Marsh lit a fire under Python tooling with Ruff and then uv. Today he’s back with something on the other side of that coin: pyx. Pyx isn’t a PyPI replacement. Think server, not just index. It mirrors PyPI, plays fine with pip or uv, and aims to make installs fast and predictable by letting a smart client talk to a smart server. When the client and server understand each other, you get new fast paths, fewer edge cases, and the kind of reliability teams beg for. If Python packaging has felt like friction, this conversation is traction. Let’s get into it. Episode sponsors Six Feet Up Talk Python Courses Links from the show Charlie Marsh on Twitter: @charliermarsh Charlie Marsh on Mastodon: @charliermarsh Astral Homepage: astral.sh Pyx Project: astral.sh Introducing Pyx Blog Post: astral.sh uv Package on GitHub: github.com UV Star History Chart: star-history.com Watch this episode on YouTube: youtube.com Episode #520 deep-dive: talkpython.fm/520 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @[email protected] X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @[email protected] Michael on X.com: @mkennedy

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• #519: Data Science Cloud Lessons at Scale

  Today on Talk Python: What really happens when your data work outgrows your laptop. Matthew Rocklin, creator of Dask and cofounder of Coiled, and Nat Tabris a staff software engineer at Coiled join me to unpack the messy truth of cloud-scale Python. During the episode we actually spin up a 1,000 core cluster from a notebook, twice! We also discuss picking between pandas and Polars, when GPUs help, and how to avoid surprise bills. Real lessons, real tradeoffs, shared by people who have built this stuff. Stick around. Episode sponsors Seer: AI Debugging, Code TALKPYTHON Talk Python Courses Links from the show Matthew Rocklin: @mrocklin Nat Tabris: tabris.us Dask: dask.org Coiled: coiled.io Watch this episode on YouTube: youtube.com Episode #519 deep-dive: talkpython.fm/519 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @[email protected] X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @[email protected] Michael on X.com: @mkennedy

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• #518: Celebrating Django's 20th Birthday With Its Creators

  Twenty years after a scrappy newsroom team hacked together a framework to ship stories fast, Django remains the Python web framework that ships real apps, responsibly. In this anniversary roundtable with its creators and long-time stewards: Simon Willison, Adrian Holovaty, Will Vincent, Jeff Triplett, and Thibaud Colas, we trace the path from the Lawrence Journal-World to 1.0, DjangoCon, and the DSF; unpack how a BSD license and a culture of docs, tests, and mentorship grew a global community; and revisit lessons from deployments like Instagram. We talk modern Django too: ASGI and async, HTMX-friendly patterns, building APIs with DRF and Django Ninja, and how Django pairs with React and serverless without losing its batteries-included soul. You’ll hear about Django Girls, Djangonauts, and the Django Fellowship that keep momentum going, plus where Django fits in today’s AI stacks. Finally, we look ahead at the next decade of speed, security, and sustainability. Episode sponsors Seer: AI Debugging, Code TALKPYTHON Sentry AI Monitoring, Code TALKPYTHON Talk Python Courses Links from the show Guests Simon Willison: simonwillison.net Adrian Holovaty: holovaty.com Will Vincent: wsvincent.com Jeff Triplett: jefftriplett.com Thibaud Colas: thib.me Show Links Django's 20th Birthday Reflections (Simon Willison): simonwillison.net Happy 20th Birthday, Django! (Django Weblog): djangoproject.com Django 2024 Annual Impact Report: djangoproject.com Welcome Our New Fellow: Jacob Tyler Walls: djangoproject.com Soundslice Music Learning Platform: soundslice.com Djangonaut Space Mentorship for Django Contributors: djangonaut.space Wagtail CMS for Django: wagtail.org Django REST Framework: django-rest-framework.org Django Ninja API Framework for Django: django-ninja.dev Lawrence Journal-World: ljworld.com Watch this episode on YouTube: youtube.com Episode #518 deep-dive: talkpython.fm/518 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @[email protected] X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @[email protected] Michael on X.com: @mkennedy

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