George Church on reimagining woolly mammoths and virus-proofing humans
"My ideas are often labelled as impossible, or useless, or both. Usually when people say that I'm on the right track."George Church is a geneticist, molecular engineer, and one of the pioneers of modern genomics. He's also someone who makes a habit of finding solutions to the seemingly impossible.Over the course of his career so far, George developed the first method for direct genomic sequencing, helped initiate the Human Genome Project, and founded the Personal Genome Project: making huge quantities of DNA data publicly available for research. Today, as a professor at Harvard Medical School and MIT, he’s working on some of the most headline-grabbing - and controversial - science on the planet: from the so-called "de-extinction" of woolly mammoths, to growing transplant-suitable organs in pigs, to virus-proofing humans.When inspiration strikes, there seems to be little that will slow him down - even the fact that he has narcolepsy, the neurological disorder that causes sudden sleep attacks. In fact, as George tells Professor Jim Al-Khalili, some of his best ideas come in those moments between waking and sleep...Presented by Jim Al-Khalili
Produced by Lucy Taylor for BBC Studios
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Gareth Collett on a career in bomb disposal
Movies might have us believe that bomb disposal comes down to cutting the right wire. In fact, explosive devices are complex and varied - and learning how to dispose of them safely involves intense training, as well as the ability to stay calm under pressure. This was the world of Dr Gareth Collett, a retired British Army Brigadier General and engineer, specialising in bomb disposal; whose 32-year military career took him around the world, including heading up major ordnance clearance projects in Iraq and Afghanistan. After retiring from the army, Gareth became a university lecturer – but following his diagnosis with bladder cancer, started researching a possible link between bomb disposal veterans and higher rates of urological cancers.In conversation with Professor Jim Al-Khalili, Gareth discusses this ongoing research, dealing with PTSD - and why he just can't watch Oscar-winning movie The Hurt Locker...Presented by Jim Al-Khalili
Produced by Lucy Taylor for BBC Studios
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Sonia Gandhi on building model brains to tackle Parkinson’s disease
Many people will be familiar with Parkinson’s disease: the progressive brain disorder that causes symptoms including tremors and slower movement, leading on to serious cognitive problems. You might not know that it’s the fastest-growing neurological condition in the world. Today it affects around 11.8 million people and that’s forecast to double by 2030. Dr Sonia Gandhi is one of the scientists working to change that trend. As Professor of Neurology at University College London and Assistant Research Director at the Francis Crick Institute, her work involves using stem cells to build models of the human brain, helping to drive the development of drugs and other therapies for Parkinson’s patients.Talking to Professor Jim Al-Khalili, Sonia explains why this destructive condition is on the rise - and the promising routes they're studying to find new ways to tackle it.Presented by Jim Al-Khalili
Produced by Lucy Taylor for BBC StudiosFor details of organisations that offer advice and support to anyone affected by Parkinson's Disease, please go online to bbc.co.uk/actionline.
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Mark O'Shea on close encounters with venomous snakes
How do you feel about snakes? What about highly venomous ones?For Mark O’Shea, close encounters with the world’s most rare and deadly snakes are not only his profession, but his passion.
Mark is a Professor of Herpetology - the area of zoology focusing on reptiles and amphibians - at the University of Wolverhampton.After dropping out of college in his teens, Mark's life could have taken a very different direction; but prompted by a fascination with reptiles that started with a childhood trip to the zoo, he's gone on to have a career spanning research, international expeditions and broadcasting. He's also worked with international medical teams, studying deadly species and helping to generate antidotes for some of the world’s deadliest venoms.In conversation with Professor Jim Al-Khalili, Mark reveals the challenges around generating antivenom for countries that need it, the pros and cons of keeping snakes as pets, and what you need to know if you ever get bitten...Presented by Jim Al-Khalili
Produced by Lucy Taylor for BBC Studios
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Kevin Fong on medical planning for Mars and Earth-based emergencies
There can't be many people in the world who've saved lives in hospital emergency rooms and also helped care for the wellbeing of astronauts in space – but Kevin Fong’s career has followed a singular path: from astrophysics and trauma medicine, to working with NASA, to becoming an Air Ambulance doctor.Kevin is a consultant anaesthetist and professor of public engagement and innovation at University College London. He’s worked on the front line in hospitals, dealing with major incidents and helping shape policy; but he's also stayed true to his childhood passion for space, working on multiple projects with NASA and even going through the astronaut application process himself. As if that wasn’t enough, he’s also become a well-known figure in science broadcasting through his various radio and TV shows.Speaking to Professor Jim Al-Khalili, Kevin admits it hasn't always been an easy path – but his passion for both space and medicine have got him through. And today, he's channelling his energies into ensuring we protect the NHS's most precious commodity: its staff.Presented by Jim Al-Khalili
Produced by Lucy TaylorThis programme was a BBC Studios Audio prouction for Radio 4.
Professor Jim Al-Khalili talks to leading scientists about their life and work, finding out what inspires and motivates them and asking what their discoveries might do for us in the future
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