The Body of Evidence

Why is endometriosis so hard to diagnose and why do most people not really know what it is? For something so common, endometriosis is rarely talked about. Until today.



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Hosts:     Christopher Labos & Sophie Tseng Pellar
Editor:    Robyn Flynn
Researcher: Danielle Kaprelian
Theme music: "Fall of the Ocean Queen" by Joseph Hackl
Rod of Asclepius designed by Kamil J. Przybos
Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer
 
Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information.



References:
ESHRE guideline: endometriosis https://pubmed.ncbi.nlm.nih.gov/35350465/
 
Time to Diagnose Endometriosis: Current Status, Challenges and Regional Characteristics-A Systematic Literature Review https://pubmed.ncbi.nlm.nih.gov/39373298/
 
Barriers to a Timely Diagnosis of Endometriosis: A Qualitative Systematic Review https://pubmed.ncbi.nlm.nih.gov/37441792/ 
 
Factors Associated with Time to Endometriosis Diagnosis in the United States https://pubmed.ncbi.nlm.nih.gov/28440744/ 
 
Rethinking the pathogenesis of endometriosis: Complex interactions of genomic, epigenetic, and environmental factors https://pubmed.ncbi.nlm.nih.gov/39293995/
 
The Immunopathophysiology of Endometriosis https://pubmed.ncbi.nlm.nih.gov/30054239/
 
Unus pro omnibus, omnes pro uno: A novel, evidence-based, unifying theory for the pathogenesis of endometriosis https://pubmed.ncbi.nlm.nih.gov/28571791/
 
Navigating towards precision: evaluating the clinical value of non-invasive biomarkers for the diagnosis of endometriosis https://pubmed.ncbi.nlm.nih.gov/38576337/
 
ACOG Publishes New Endometriosis Clinical Guidance, Aiming to Shorten Time to Diagnosis and Improve Access to Care https://www.acog.org/news/news-releases/2026/02/acog-publishes-new-endometriosis-clinical-guidance-aiming-shorten-time-diagnosis-improve-access-care
 
Diagnosis of Endometriosis https://www.acog.org/clinical/clinical-guidance/clinical-practice-guideline/articles/2026/03/diagnosis-of-endometriosis

Polycystic ovarian syndrome now has a new name, polyendocrine metabolic syndrome. But not everyone is happy. Is this progress or just a label swap?



Become a supporter of our show today either on Patreon or through PayPal! Thank you!
http://www.patreon.com/thebodyofevidence/
https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE
 
Email us your questions at thebodyofevidence@gmail.com.



Hosts:     Christopher Labos & Sophie Tseng Pellar
Editor:    Robyn Flynn
Researcher: Danielle Kaprelian
Theme music: "Fall of the Ocean Queen" by Joseph Hackl
Rod of Asclepius designed by Kamil J. Przybos
Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer
 
Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information.



References:
 
The Lancet (2026): Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process - ScienceDirect
 
International Evidence-Based Guideline for the Assessment and Management of PCOS: International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome 2023 - Monash University
 
Historical / context
NIH Methodology Workshop (2012): Evidence-based Methodology Workshop on Polycystic Ovary Syndrome (PCOS) | NIH Office of Disease Prevention Website 
 
Commentary / debate
JAMA Medical News (2026): PCOS Is Now PMOS—Will a New Name Translate to Improved Clinical Care? | Reproductive Health | JAMA | JAMA Network
BMJ Commentary (2026): PCOS name change to PMOS must be managed to avoid confusing patients, says expert | The BMJ
 
Patient-facing summaries
Endocrine Society (2026): Polyendocrine Metabolic Ovarian Syndrome: New name to improve diagnosis and care of condition affecting 170 million women worldwide | Endocrine Society
Yale Medicine (2026): PCOS Is Renamed PMOS: What You Need to Know | News | Yale Medicine

Protein maxxing is all the rage and the new dietary guidelines in the US recently doubled the recommended amount of protein intake. But will a high protein diet help you lose weight and will it really help you build more muscle?



Become a supporter of our show today either on Patreon or through PayPal! Thank you!
http://www.patreon.com/thebodyofevidence/
https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE
 
Email us your questions at thebodyofevidence@gmail.com.



Hosts:     Christopher Labos & Sophie Tseng Pellar
Editor:    Robyn Flynn
Researcher: Auriane Journet
Theme music: "Fall of the Ocean Queen" by Joseph Hackl
Rod of Asclepius designed by Kamil J. Przybos
Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer
 
Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information.



References:
 
Clinthorne, J., Leidy, H. J., & Sollid, K. (2026). A Modern Take on Protein Nutrition Meets Evolving Consumer Perceptions. The Journal of nutrition, 156(5), 101477. https://doi.org/10.1016/j.tjnut.2026.101477 

Devries, M. C., Sithamparapillai, A., Brimble, K. S., Banfield, L., Morton, R. W., & Phillips, S. M. (2018). Changes in Kidney Function Do Not Differ between Healthy Adults Consuming Higher- Compared with Lower- or Normal-Protein Diets: A Systematic Review and Meta-Analysis. The Journal of nutrition, 148(11), 1760–1775. https://doi.org/10.1093/jn/nxy197 

Hägele, F. A., Herpich, C., Koop, J., Grübbel, J., Dörner, R., Fedde, S., Götze, O., Boirie, Y., Müller, M. J., Norman, K., & Bosy-Westphal, A. (2025). Short-term effects of high-protein, lower-carbohydrate ultra-processed foods on human energy balance. Nature metabolism, 7(4), 704–713. https://doi.org/10.1038/s42255-025-01247-4

Health Canada. Canada's Dietary Guidelines for Health Professionals and Policy Makers. Government of Canada; 2019. canada.ca/en/health-canada/services/food-guide/explore/dietary-guidelines

Helms, E. R., Aragon, A. A., & Fitschen, P. J. (2014). Evidence-based recommendations for natural bodybuilding contest preparation: nutrition and supplementation. Journal of the International Society of Sports Nutrition, 11, 20. https://doi.org/10.1186/1550-2783-11-20

International Food Information Council. 2025 IFIC Food & Health Survey: The Full Report. January 2026. https://ific.org/research/2025-food-health-survey

Jäger, R., Kerksick, C. M., Campbell, B. I., Cribb, P. J., Wells, S. D., Skwiat, T. M., Purpura, M., Ziegenfuss, T. N., Ferrando, A. A., Arent, S. M., Smith-Ryan, A. E., Stout, J. R., Arciero, P. J., Ormsbee, M. J., Taylor, L. W., Wilborn, C. D., Kalman, D. S., Kreider, R. B., Willoughby, D. S., Hoffman, J. R., … Antonio, J. (2017). International Society of Sports Nutrition Position Stand: protein and exercise. Journal of the International Society of Sports Nutrition, 14, 20. https://doi.org/10.1186/s12970-017-0177-8

Leidy, H. J., Clifton, P. M., Astrup, A., Wycherley, T. P., Westerterp-Plantenga, M. S., Luscombe-Marsh, N. D., Woods, S. C., & Mattes, R. D. (2015). The role of protein in weight loss and maintenance. The American journal of clinical nutrition, 101(6), 1320S–1329S. https://doi.org/10.3945/ajcn.114.084038

Morton, R. W., Murphy, K. T., McKellar, S. R., Schoenfeld, B. J., Henselmans, M., Helms, E., Aragon, A. A., Devries, M. C., Banfield, L., Krieger, J. W., & Phillips, S. M. (2018). A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. British Journal of Sports Medicine, 52(6), 376–384. https://doi.org/10.1136/bjsports-2017-097608

Pasiakos SM, Davis TA, Klurfeld DM, Neuhouser ML, Rodriguez NR, Tomé D. Perspectives on the protein recommendations in the 2025-2030 Dietary Guidelines for Americans. J Nutr 2026.

US Departments of Agriculture and Health and Human Services. Dietary Guidelines for Americans, 2025-2030.

Wycherley TP, Moran LJ, Clifton PM, et al. Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of RCTs. Am J Clin Nutr 2012;96(6):1281-1298. doi:10.3945/ajcn.112.044321

The United States outspends every other country on Earth on healthcare but shockingly does not have the best outcomes and ranks 32nd in terms of life expectancy. Switzerland spends less and does better. Plucky little Canada ranks 22nd in the world. Kim Moon is back to explain why more spending doesn't equal better outcomes and what really drives higher health care costs. Also, a comparative analysis of the US and Canadian healthcare systems: what works and what doesn't in each country.
 
Become a supporter of our show today either on Patreon or through PayPal! Thank you!
http://www.patreon.com/thebodyofevidence/
https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE
 
Email us your questions at thebodyofevidence@gmail.com.



Hosts:     Christopher Labos & Kim Moon
Editor:    Robyn Flynn
Theme music: "Fall of the Ocean Queen" by Joseph Hackl
Rod of Asclepius designed by Kamil J. Przybos
Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer
 
Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information.



References:
The richest Americans live about as long as the poorest Europeans, study says : NPR

 
U.S. Health Care from Global Perspective 2026 Expanded Edition | Commonwealth Fund

 
How does U.S. life expectancy compare to other countries? - Peterson-KFF Health System Tracker

 
Hospital Global Budgeting: Lessons from Maryland and Selected Nations

 
The U.S. Health Disadvantage and Why It Matters to Business - Community Health and Economic Prosperity - NCBI Bookshelf

 
Expanding healthcare capacity in Canada: the potential of internationally trained physicians - ScienceDirect

 
Troubling Diagnosis: Comparing Canada's Healthcare with International Peers – C.D. Howe Institute

 
Life expectancy at birth: Health at a Glance 2025 | OECD

 
Seven reasons why Americans pay more for health care than any other nation

 
Canada | Commonwealth Fund

 
State of Health Insurance Coverage in U.S.: 2024 Biennial Survey | Commonwealth Fund

 
Health Spending - International Comparison of Health Systems | KFF

 
Canadians need doctors. These strategies from around the country aim to find them | CBC News

 
'You Aren't Trapped': Hundreds of US Nurses Choose Canada Over Trump's America - KFF Health News

 
COMMENTARY: 5 affordable ways to improve Canadians' access to health care in 2026 | CMA

We're back with another review of the show that will outlive us all. Grey's Anatomy part 3 with cases like the boy who lived in a plastic bubble, the man who believed he was pregnant, the competitive eater who ate too much, the woman who felt no pain, and the patient who could hear everything during surgery.
 
Become a supporter of our show today either on Patreon or through PayPal! Thank you!
http://www.patreon.com/thebodyofevidence/
https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE
 
Email us your questions at thebodyofevidence@gmail.com.



Hosts:     Christopher Labos & Robyn Flynn
Editor:    Robyn Flynn
Researcher: Danielle Kaprelian
Theme music: "Fall of the Ocean Queen" by Joseph Hackl
Rod of Asclepius designed by Kamil J. Przybos
Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer
 
Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information.