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This Week in Virology

Vincent Racaniello
This Week in Virology
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  • TWiV 1221: Nonsense mediated decay
    TWiV reviews cuts in National Science Foundation budgets, cuts to Harvard University grants, judge blocks ban on Harvard enrolling international students, DOGE ordered cuts of NIH grants, endemic coronavirus infection induces Fc receptor binding antibodies to SARS-CoV-2, and inherited IFNAR1 deficiency causing adverse reactions to measles and yellow fever infectious vaccines. Hosts: Vincent Racaniello, Alan Dove, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV NSF funding cut to lowest level (NY Times) 1,000 grants cut at Harvard University (Nature) Administration ban on international students at Harvard blocked (CNN) DOGE killed NIH grants (Nature) Endemic coronavirus infection induces FcR binding antibodies to SARS-CoV-2 (J Virol) IFNAR1 deficiency and severe reaction to measles and yellow fever vaccines (J Exp Med) Letters read on TWiV 1221 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Angela – Contact lenses that give people infrared vision — even with their eyes shut (one, two) Alan –  Autocrats are afraid of you – see the graphic, especially. Vincent – How One Company Secretly Poisoned The Planet Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.
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  • TWiV 1220: Clinical update with Dr. Daniel Griffin
    In his weekly clinical update, Dr. Griffin with Vincent Racaniello debate the changes in FDA vaccine approval policy especially how it is applied to COVID-19 vaccines and restricts vaccine availability/usage and Novavax’s vaccine, mpox on surfaces and in the air, “bird flu”, the ongoing measles outbreak globally before Dr. Griffin reviews recent statistics on RSV, benefits of vaccination for infants, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, the high number of childhood deaths during this “flu” season, the May 22 VRBPAC COVID-19 vaccine meeting, where to find PEMGARDA, prolonged steroid and antibiotic therapies, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, cognitive impairment in long COVID and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA to issue new vaccine approval guidance amid questions over coronavirus shots (Washington Post) FDA vaccine committee meeting(Reuters) Evidence-based approach to COVID-19 vaccination (NEJM) FDA CBER townhall: new COVID019 vaccination approval mechanism (YouTube) FDA poised to restrict access to COVID vaccines, our own Dr. Griffin is cited! (NY Times) Novavax approval letter (FDA) We giveth and taketh away: Novavax approved but restricted use (AP News) FDA approves Novavax COVID vaccine with stricter new conditions (NY Times) History behind public health falsehoods– vaccine and autism (NPR) Making vaccines less accessible-RFK Jr making MAHA! (PBS News Hour) Kenneday says DO NOT to take medical advice from him, the HHS secretary…hummmm (NY Times) Staying up to date with COVID-19 vaccines (CDC: COVID-19) How science lost America’s trust and surrendered health policy to skeptics (WSJ) HHS stops recommendation of COVID-19 shots for children and pregnant women (Reuters) No more routine COVID-19 vaccines for children and pregnant women (WSJ) House to investigate Pfizer for allegedly delaying COVID-19 vaccines (Reuters) Statement on the antigen composition of COVID-19 vaccines (WHO) WHO advisers say current strains OK for COVID vaccine production (CIDRAP) We can’t remain indifferent to suffering: Catholic Church now champions HPV vaccination (DailyNation) Air and surface sampling for mpox in UK (Eurosurveillance) Researchers report mpox DNA, live virus on surfaces and in air from patients’ rooms(CIDRAP) USDA reported H5N1 bird flu detection in wild birds (CDC: Avian Influenza) USDA reported H5N1 in poultry (CDC: Avian Influenza) HPAI Confirmed Cases in Livestock(USDA Animal and Plant Health Inspections Service) H5 bird flu: current situation (CDC: Avian Influenza) Bird flu (CDC: Avian Influenza) Measles cases and outbreaks (CDC Rubeola) Measles and rubella weekly monitoring report: (Government of Canada) Measles vaccine recommendations from NYP (jpg)  Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola) Measles vaccine (CDC Measles (Rubeola) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Weekly surveillance report: clift notes (CDC FluView) Respiratory virus activity levels (CDC Respiratory Illnesses) Weekly surveillance report: clift notes (CDC FluView) FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) RSV: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States (CDC: COVID-19) COVID-19 vaccine VRBPAC May 22 (FDA) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) The clinical impact of prolonged steroid therapy in severe COVID-19 patients (BMC Pulmonary Medicine) Anticoagulation guidelines (hematology.org) Antibiotic Treatment in Patients Hospitalized for Nonsevere COVID-19 (JAMA Network Open) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Self-reported health, neuropsychological tests and biomarkers in fully recovered COVID-19 patients vs patients with post-COVID cognitivesymptoms (PLoS One) Vortioxetine for Cognitive Impairment in Major Depressive Disorder During Post-COVID Syndrome (Journal of Clincial Psychiatrist) Reaching out to US house representative Letters read on TWiV 1220 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected] Content in this podcast should not be construed as medical advice.
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  • TWiV 1219: Koalas sweep horse shift
    TWiV reviews pause in the use of Chikungunya vaccine, HHS to stop recommending COVID shots for pregnant women and children, molecular basis for shifted receptor recognition by an encephalitic alphavirus, and evolution of koala retrovirus transcriptional silencing in wild koalas. Hosts: Vincent Racaniello, and Rich Condit Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Pause in use of Ixchiq (FDA) Change in COVID vaccine recommendations (STAT) Basis for receptor shift in encephalitic alphavirus (Cell) Transcriptional silencing of koala retrovirus (Cell) Letters read on TWiV 1219 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Rich – What’s that stuff in your bellybutton? Science has the answer. Vincent – New study reveals our skin’s own bacteria can help protect us from the bad effects of sunlight Listener Pick Rona – My Italian secret: the forgotten heroes and Italy and the Holocaust Foundation, Inc. Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.
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  • TWiV 1218: Clinical update with Dr. Daniel Griffin
    In his weekly clinical update, Dr. Griffin with Vincent Racaniello wail about the attack on science within the US, cancellation of CDC’s committee on infectious diseases, mpox in Sierra Leone, “bird flu” in cats, the ongoing measles outbreak globally, before Dr. Griffin reviews recent statistics on RSV, benefits of vaccination for infants, influenza and SARS-CoV-2 infections the WasterwaterScan dashboard, the high number of childhood deaths during this “flu” season, the May 22 VRBPAC COVID-19 vaccine meeting, where to find PEMGARDA, benefit of remedesivir, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, weight and distinct symptoms of long COVID and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Shut down federal advisory committee on infection prevention…..Make America Healthy Again! (CIDRAP) Mpox in Sierra Leone (CIDRAP) H5 Bird Flu: Current Situation (CDC: Avian Influenza (Bird Flu) ) Spike in avian flu cases in cats : spillover into humans? (CIDRAP) Measles cases and outbreaks (CDC Rubeola) Measles 800 in Texas…. (Texas Health and Human Services) Measles outbreak in North Dakota prompts local health officials to quarantine unvaccinated schoolchildren (CNN) 2025 Measles outbreak guidance (New Mexico Health) Measles and rubella weekly monitoring report: (Government of Canada) The Mennonites in a Texas community where measles is spreading (AP News) Trust the government? Seriously! West Texans, Mennonites at center of measles outbreak choose medical freedom over vaccine mandates (AP News) Measles vaccine recommendations from NYP (jpg)  Deporting Measles! (AP News) Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Measles (CDC Measles (Rubeola)) Measles (CDC: Measles Rubeola) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Weekly surveillance report: clift notes (CDC FluView) Respiratory virus activity levels (CDC Respiratory Illnesses) CDC reports 216 child deaths this flu season (AP News) Weekly surveillance report: clift notes (CDC FluView) New York sees highest flu-related pediatric deaths ever recorded in a season (Times Union) Phase 3 Safety and Efficacy Study of Baloxavir Marboxil in Children Less Than 1 Year Old With Suspected or Confirmed Influenza (The Pediatric Infectious Disease Journal) FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) RSV: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Interim Evaluation of Respiratory Syncytial Virus Hospitalization Rates Among Infants and Young Children After Introduction of Respiratory Syncytial Virus Prevention Products (CDC: MMWR) US infant mortality dropped in 2024: RSV vaccine? (AP News) Infant Mortality Dashboard (CDC: National Center for Health Statistics) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) Wastewater Measures of SARS-CoV-2 Accurately Predict Frequency of Symptomatic Infections in the Community (JID) Origin of SARS-CoV-2 The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2 (Cell) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) COVID-19 infection history as a risk factor for early pregnancy loss (BMC Medicine) New recommendations seek treatments for post-Lyme disease condition (CIDRAP) Immunogenicity and Safety of Influenza and COVID-19 Multicomponent Vaccine in Adults ≥50 YearsA Randomized Clinical Trial (JAMA) Combo flu-COVID vaccine shows good immune response, safety in older adults (CIDRAP) US FDA advisers to discuss COVID-19 vaccine recommendations on May 22 (Reuters) Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States (CDC: COVID-19) COVID-19 vaccine VRBPAC May 22 (FDA) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Remdesivir associated with reduced mortality in hospitalized COVID-19 patients (BMC Infectious Diseases) Real-world evidence shows remdesivir tied to less death in hospitalized COVID patients (CIDRAP) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Excess weight is associated withneurological and neuropsychiatric symptoms in post-COVID-19 condition (PLoS One) Identification of soluble biomarkers that associate with distinct manifestations of long COVID (Nature Immunology) Reaching out to US house representative Letters read on TWiV 1218 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected] Content in this podcast should not be construed as medical advice.
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  • TWiV 1217: Alternative vax and pandemic origins
    TWiV reviews new CBER chief at FDA, ending of Gates Foundation in 2045, gain of function executive order, origins of bat viruses ancestral to SARS-CoV and SARS-CoV-2, and single dose Sudan virus replicon vaccine protects guinea pigs from disease. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Prasad replaces Marks at FDA (US News) Gates Foundation ends 2025 (Gates Foundation) Gain of function Executive Order (White House) DURC policy (HHS) Origins of bat viruses ancestral to SARS-CoV and SARS-CoV-2 (Cell) Sudan virus replicon vaccine (Nat Comm) Letters read on TWiV 1217 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Rich – Andor Season 2 Alan – Sequencing Mendel’s pea plant traits, and a good Science news article on the work Vincent – 2023 summer warmth unparalleled over the past 2,000 years Listener Pick Brian – Virology Capabilities Test (VCT): A Multimodal Virology Q&A Benchmark Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.
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This Week in Virology is a netcast about viruses - the kind that make you sick.
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