Joint Action

• Is Methotrexate ready for clinical use? A discussion with Professor Robin Christensen and Dr Anna Dossing

  Methotrexate is a well-established drug used in oncology, but could it also play a role in managing osteoarthritis? In this episode of Joint Action, Professor David Hunter is joined by Dr Anna Døssing and Professor Robin Christensen to explore the potential of methotrexate as a treatment for osteoarthritis pain. They discuss:What methotrexate is and how it worksInsights from a recent meta-analysis on its effectiveness and safetyWhy individual studies show mixed resultsWhether it might help people with hand or knee OA - especially those with signs of inflammationHow dosing and side effects factor into clinical decision-making Tune in for an honest, data-driven conversation about repurposing an old drug for a new purpose - and what it could mean for people living with osteoarthritis.RESOURCESEditorial: Methotrexate for osteoarthritis—Ready for clinical use and in whom?: https://www.oarsijournal.com/article/S1063-4584(25)00973-2/abstract?CONNECT WITH USTwitter: @ProfDavidHunter @jointactionorgInstagram: @osteoarthritisresearchgroupEmail: [email protected]: https://www.jointaction.info/podcast Hosted on Acast. See acast.com/privacy for more information.

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• Can a diabetes pill help with knee pain? A discussion with Professor Flavia Cicuttini

  Metformin is one of the world’s most prescribed drugs for type 2 diabetes - but could it also help with knee osteoarthritis? In this episode of Joint Action, Prof. David Hunter is joined by Prof. Flavia Cicuttini to unpack the results of a groundbreaking clinical trial that tested metformin as a new treatment for knee pain in people with knee osteoarthritis. Tune in to hear what the study found, how the drug works, who might benefit, and what this could mean for delaying joint replacement. RESOURCES Article: Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity: https://jamanetwork.com/journals/jama/article-abstract/2833338 CONNECT WITH USTwitter: @ProfDavidHunter @jointactionorgInstagram: @osteoarthritisresearchgroupEmail: [email protected]: https://www.jointaction.info/podcast Hosted on Acast. See acast.com/privacy for more information.

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• Is osteoarthritis treatment worth the cost? With Dr Stephanie Mathieson and Dr Giovanni Ferreira

  In this episode of Joint Action, Professor David Hunter is joined by Dr. Stephanie Mathies and Dr. Giovanni Ferreira to unpack the cost-effectiveness of osteoarthritis treatments. They discuss the results of their recent systematic review, which analysed over 100 studies to identify which guideline-recommended treatments provide the best value for money.From exercise and medications to injections and surgery, they explore which interventions are truly cost-effective - and which may not be worth the spend. Learn why “simple things” like exercise and education still offer the most value, and what this means for patients, clinicians, and healthcare policy.RESOURCESArticle:The cost-effectiveness of guideline-recommended treatments for osteoarthritis: A systematic review: https://www.oarsijournal.com/article/S1063-4584(25)00972-0/abstractCONNECT WITH USTwitter: @ProfDavidHunter @jointactionorgInstagram: @osteoarthritisresearchgroupEmail: [email protected]: https://www.jointaction.info/podcast Hosted on Acast. See acast.com/privacy for more information.

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• Walking for joint health with Dr Sarah Kobayashi

  In this week's episode of Joint Action, Professor David Hunter is joined by Dr Sarah Kobayashi, a lecturer in anatomy and osteoarthritis researcher, to talk about the power of walking - especially for people with osteoarthritis.Sarah shares her insights into the many health benefits of walking, why it’s so important for joint health, and how to overcome common barriers to getting started. She also introduces the CASCADE-OA study (Community bAsed phySical aCtivity AnD sElf-management for OsteoArthritis), a 12-month clinical trial exploring the effectiveness of a self-directed walking program, Walk With Ease Australia, in improving physical activity levels and managing symptoms for those with hip or knee osteoarthritis.Whether you're new to walking or looking to establish a sustainable routine, this episode offers practical advice and motivation to help you take that first step.RESOURCES Learn more about the CASCADE-OA study and check your eligibility:CASCADE-OA Study Overview: www.osteoarthritisresearch.com.au/cascadeoa-study-overviewAsk your local arthritis organisation about Walk With Ease or the CASCADE-OA study: Arthritis Australia – www.arthritisaustralia.com.au/state-offices/Additional resources:Versus Arthritis Walking Guide (UK): www.versusarthritis.org/about-arthritis/exercising-with-arthritis/exercises/walkingHeart Foundation Walking Groups (Australia) – walking.heartfoundation.org.auParkrun Australia: www.parkrun.com.auCONNECT WITH US Twitter: @ProfDavidHunter @jointactionorgInstagram: @osteoarthritisresearchgroupEmail: [email protected]: www.jointaction.info/podcast Hosted on Acast. See acast.com/privacy for more information.

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• Rethinking running and knee health with Dr Jean-Francois Esculier

  Running often gets a bad rap when it comes to knee osteoarthritis - but is the fear justified? In this week's episode of Joint Action, Professor David Hunter speaks with physiotherapist and researcher Dr Jean-François Esculier to unpack common myths about running and joint health. They explore the latest evidence, share tips for safe running with OA, and discuss how to build joint resilience over time.Tune in to learn why running might not just be safe - it could even be helpful.RESOURCESEducation resource on running and joint health, in 7 languages: http://hdl.handle.net/2429/82767 CONNECT WITH USTwitter: @ProfDavidHunter @jointactionorgInstagram: @osteoarthritisresearchgroupEmail: [email protected]: www.jointaction.info/podcast Hosted on Acast. See acast.com/privacy for more information.

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