Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

When is the best time to take L-theanine—for daytime anxiety, before bed, or when you wake during the night?
In this short Q&A episode of The Histamine Well Podcast, Joanne discusses how she uses L-theanine to support relaxation and explains how timing may differ depending on your symptoms. She also explores combining L-theanine with magnesium and the options she discusses when magnesium glycinate isn’t tolerated.
In this episode, you’ll learn:
How Joanne uses L-theanine for daytime anxiety and nervous system hyperarousal.
When she considers taking it before bed for difficulty falling asleep.
How she approaches L-theanine timing for waking during the night.
The doses and supplement combinations discussed in her clinical approach.
Why individual tolerance matters when choosing magnesium.
If you’ve been wondering when to take L-theanine for anxiety or sleep, this quick episode explores the timing options Joanne considers in practice.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Bloating, constipation, and food reactions after food poisoning—could SIBO be part of the picture?
In this episode of The Histamine Well Podcast, Joanne walks through a real patient case of small intestinal bacterial overgrowth (SIBO), exploring persistent digestive symptoms, a methane-positive breath test, and suspected histamine-related reactions.
The patient had experienced significant bloating, nausea, reflux, constipation and brain fog, with probiotics making her bloating worse. Despite seeing several practitioners, she had not been assessed for SIBO.
Joanne shares the clues that prompted testing, why she prioritised a SIBO breath test over stool microbiome testing in this case, and how she introduced a SIBO low-histamine diet and personalised digestive support.
At her first follow-up, the patient reported an 80% reduction in bloating, alongside improvements in nausea, reflux and heartburn. With constipation still an issue, Joanne explains the next adjustments to her care and why retesting remained part of the plan.
In this episode, you’ll hear:
The patient’s symptom history following food poisoning.
Joanne’s reasoning behind targeted SIBO testing.
How the methane-positive result informed her approach to constipation.
The dietary changes and digestive support used initially.
How Joanne adjusted the plan as symptoms improved.
Her plans for follow-up, retesting and food reintroduction.
Whether you’re experiencing ongoing gut symptoms or supporting patients in clinical practice, this episode offers a practical look at Joanne’s assessment and treatment decisions.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Have you noticed low mood or sadness after taking calcium D-glucarate? If you’re using it to support oestrogen detoxification or address high beta-glucuronidase on a gut test, your stage of life and hormone levels deserve consideration.

In this short Q&A episode of The Histamine Well, Joanne explores why calcium D-glucarate may not suit everyone, particularly during perimenopause and menopause. She discusses the potential connection between oestrogen clearance and mood, and shares her own experience of feeling unusually sad while taking the supplement.

If a supplement leaves you feeling worse, that experience deserves attention. Listen to hear why Joanne encourages a closer look at your hormones, symptoms and treatment plan.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Could your gut help explain why you’re reacting to foods you once tolerated?
In this episode of The Histamine Well, Joanne explores the connection between gut health and histamine intolerance, explaining how the microbiome, intestinal lining, immune system, and nervous system interact.
A low histamine diet may help reduce symptoms, but what happens when the gut itself is contributing to your histamine burden? Joanne discusses SIBO, dysbiosis, histamine-producing bacteria, mast cells, and the DAO enzyme—and why understanding the underlying contributors matters.
What you’ll learn:
How the intestinal barrier and secretory IgA help protect your gut.
Why microbial diversity, butyrate and immune tolerance matter.
How SIBO, dysbiosis and intestinal inflammation may contribute to histamine symptoms.
How mast cells and certain gut bacteria produce histamine.
Why intestinal health matters for DAO, the enzyme that helps break down dietary histamine.
How stress, the nervous system, and gut motility can influence digestive symptoms.
Why gut support needs to be personalised to your symptoms and tolerance.
Whether you’re navigating histamine intolerance yourself or supporting patients in clinical practice, this episode offers a clearer understanding of the gut–immune connection.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

A low FODMAP diet is often used to reduce bloating, so why might your symptoms get worse after starting one?
In this short Q&A episode, Joanne explores three possibilities: eating more sulfur-rich foods, replacing wheat with higher-oxalate ingredients, and changes in gut motility, including the migrating motor complex. She explains why it’s worth looking at what has changed in your diet instead of simply pushing through worsening bloating.
In this episode:
How food swaps on a low FODMAP diet may increase your sulfur or oxalate intake
Symptoms Joanne suggests watching for alongside bloating
Why the migrating motor complex may matter when bloating persists
Why a SIBO test can help clarify what may be going on
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!