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The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
The Human Upgrade: Biohacking for Longevity & Performance
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  • Facelifts, Breast Implants, and the REAL Fix for Wrinkles : 1300
    Wrinkles are just the surface. This episode reveals what’s really happening beneath your skin and how to reverse it using stem cells, regenerative medicine, and the most advanced techniques in plastic surgery and aging. You’ll learn how to improve facial skin tightening, reduce inflammation, and trigger deep skin rejuvenation with stem cells, red light therapy, and targeted procedures that actually work. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey shares his personal journey through weight loss and skin excess, including why he had 28 inches of skin removed and how he rebuilt facial structure using stem cells and longevity protocols. He’s joined by Dr. Victor Urzola, a globally recognized expert in plastic surgery and aging, known for pioneering biohacking skin health techniques, cutting-edge facial reconstruction, and legalizing therapeutic stem cell use in Costa Rica. Together, they expose the hidden causes of wrinkles and aging, from mitochondrial slowdown to ligament laxity and collagen depletion. They also unpack the science behind breast implant health risks, silicone toxicity syndrome, and why thousands of women experience hormonal, neurological, and metabolic symptoms related to their implants. Dr. Urzola explains how explant surgery can improve hormone balance, sleep, HRV, metabolism, and even libido. You’ll also hear how cosmetic procedures interact with HPA axis function and how skin and brain health are more connected than you think. This episode is a must for anyone serious about biohacking, skin optimization, stem cells and longevity, and functional medicine. Dave also breaks down his recovery stack, including exosomes, red light therapy, collagen cycling, nootropics, and how cosmetic procedures can be used to enhance—not just appearance—but total human performance. You’ll learn: • The real root causes of wrinkles and sagging skin • How to use skin rejuvenation with stem cells for long-term results • Signs of silicone toxicity syndrome and what to do about it • Why cosmetic procedures impact hormone health and libido • The most effective strategies for facial skin tightening and recovery• How to approach breast implant health risks with functional medicine thinking Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: Generation Lab | Go to https://www.generationlab.com/ use code Dave20 for $20 off. Qualia | Go to https://www.qualialife.com/dave15 to get an additional 15% off subscriptions. fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Dr. Urzola’s Website: https://drvictorurzola.com/en/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Labs: https://upgradelabs.com • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:39 Intro • 02:52 Breast Implants & Aesthetics • 03:40 Stem Cells in Cosmetic Procedures • 10:38 Skin Health & Anti-Aging Tips • 15:11 Red Light & Face Stimulation • 17:15 Platysma Muscle & Neck Aging • 21:01 Implant Risks & Reactions • 27:36 Vince & Longevity Science • 28:51 Implant Tolerance Explained • 29:52 Silicone Health Impact • 31:06 Inflammation & Genetics • 32:15 Explant Outcomes & Recovery • 40:14 Breastfeeding & Aesthetic Changes • 41:03 Lift vs. Implants • 45:39 Patient-First Medical Care • 53:32 Stem Cells & Medical Freedom • 56:21 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Superintelligence, Transhumanism & Biohacking in 2027 : 1299
    Superintelligence is coming faster than anyone predicted. In this episode, you’ll learn how to upgrade your biology, brain, and consciousness before AI and transhumanism reshape the future of health. Host Dave Asprey sits down with Soren Gordhamer, founder of Wisdom 2.0, to explore what superintelligence in 2027 means for your mind, body, and soul. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Soren has spent decades at the intersection of mindfulness, technology, and human development. He advises leaders at OpenAI, Google, and top wellness companies, and he leads global conversations around AI and consciousness. His work bridges ancient wisdom with biohacking, modern neuroscience, and the urgent need to stay human in a machine-dominated world. This episode gives you a tactical roadmap to build resilience before the world tilts. You’ll gain practical tools for brain optimization, functional medicine, and biohacking strategies that sharpen cognitive health, reinforce emotional stability, and unlock peak human performance in a digital-first reality. From supplements and nootropics to neuroplasticity techniques, Dave and Soren show you how to protect your biology as AI accelerates beyond human speed. They break down how AI and human health intersect, explain why you need emotional strength to face the future, and offer guidance for raising kids in a world ruled by code. If you’re preparing for 2027 superintelligence, navigating AI-driven parenting, or staying ahead of transhumanist health tech, this episode equips you for the coming wave. You’ll Learn: • How AI is reshaping human connection, presence, and identity • Why emotional resilience and conscious awareness matter more than ever in an AI-driven world • How to raise connected, grounded children in a hyper-digital environment • What human flourishing looks like when technology outpaces biology • Why investing in presence, purpose, and inner development may be the ultimate upgrade • How leaders in wellness and tech are rethinking personal growth, governance, and ethics in 2027 • What it means to stay truly human—and fully alive—during the rise of superintelligence Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes drop every Tuesday and Thursday, where Dave asks the questions no one else dares and gives you real tools to become more resilient, aware, and high performing. SPONSORS: - LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE. - ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Soren's New Book - The Essential: https://a.co/d/dALv7OS • Soren's Website: www.sorengordhamer.net • Soren's Instagram: https://www.instagram.com/wisdom2events/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Labs: https://upgradelabs.com • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Why I Add Creatine to My Coffee Every Morning (And You Should Too) : 1298
    Creatine isn’t just for bodybuilders. It’s one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy, and total human performance. This episode reveals why creatine is a non-negotiable supplement for anyone serious about biohacking, longevity, and cognitive upgrades. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey breaks down the myths and truths about creatine, uncovering how it enhances memory, supports your mitochondria, regulates mood, strengthens bones and heart function, and even aids fetal brain development during pregnancy. Drawing from decades of functional medicine, real-world biohacks, and new research featured in the Wall Street Journal, Dave explains how creatine works not only as a muscle booster but as a universal cellular fuel that supports brain benefits, memory improvement, and sleep optimization. You’ll learn how to harness creatine for everything from mental performance and mood regulation to faster recovery and better metabolism. Dave covers creatine dosage and timing, how to use creatine loading versus maintenance protocols, and how to enhance creatine absorption by mixing it with hot water or pairing it with glucose and protein to leverage insulin-sensitive pathways. He also shares next-level stacking strategies by combining creatine with caffeine (including Danger Coffee), beta-alanine, nitrates, and electrolytes to maximize both mental and physical results. Whether you’re using creatine for brain energy, sprint power, cold therapy performance, or cognitive resilience, this episode delivers practical tools you won’t hear anywhere else. If you’re following a carnivore diet, in ketosis, experimenting with fasting, or just want to feel sharper and more energized, creatine fits right in. Dave also explores cutting-edge options like GAA creatine, creatine HCL, and intranasal delivery systems, along with key nutrient pairings like TMG and folinic acid to support methylation and avoid side effects. Plus, he explains why vegetarians and vegans may need creatine the most. This is your complete guide to creatine brain benefits, mitochondrial support, memory enhancement, and smarter not harder living. You’ll Learn: • How creatine supports neuroplasticity, brain energy, and cognitive function • Why mitochondrial health is the key to memory, mood, and mental performance • The real science behind creatine dosage, absorption, and stacking strategies • How creatine fits into ketosis, fasting, and a carnivore lifestyle • Why vegans and vegetarians may suffer from creatine deficiency • How to combine creatine with caffeine, nitrates, and nootropics for peak performance • Ways to biohack your metabolism, muscle growth, and mental clarity • The link between creatine, sleep optimization, and reduced brain fog • How creatine protects against oxidative stress and supports longevity • What you need to know about GAA creatine, methylation support, and delivery mechanisms Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - Calroy | Head to https://calroy.com/dave for an exclusive discount. - BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. Resources: • Danger Coffee: https://dangercoffee.com • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:14 Creatine for Overall Health and Longevity • 06:10 Addressing Common Myths About Creatine • 08:55 How to Use Creatine Effectively • 19:58 Special Use Cases and Recommendations • 24:58 Choosing the Right Creatine • 28:41 Conclusion and Recap See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Death, Legacy & the Philosophy of Longevity — with Stephen Cave : 1297
    What if death isn’t inevitable but a solvable problem? This episode explores how biohacking is reshaping our understanding of mortality, legacy, and the limits of human performance. You’ll learn why some of today’s top thinkers are treating longevity as both a science and a spiritual movement, and how this shift affects your brain, your mitochondria, and your entire approach to life. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with philosopher and best-selling author Dr. Stephen Cave, Director of the Institute for Technology and Humanity at the University of Cambridge. With decades of expertise studying death, immortality, and ethics, Dr. Cave brings a rare depth of insight into how our desire to live longer intersects with neuroplasticity, supplements, and even nootropics. Together, they unpack the four universal immortality narratives, the dangers of mind uploading, and why AI might become humanity’s next god or destroyer. You’ll discover how legacy, ego, functional medicine, and even fasting and ketosis play into our fear of death. The conversation also dives into the deeper psychological and societal consequences of radical life extension, and what happens when biohacking crosses into belief. This episode is a must-listen for anyone serious about hacking longevity, brain optimization, metabolism, and building a future where living to 180 isn’t science fiction. You’ll also hear surprising thoughts on Danger Coffee, RFK, sleep optimization, and how to approach mortality using the Smarter Not Harder mindset. You’ll Learn: • Why all technology is a form of life extension • How ego and boredom threaten longevity more than disease • The real dangers of digital immortality and uploading consciousness • Why procrastination could be the enemy of eternal life • How to balance transhumanist tech with human values • The surprising connection between cold therapy, supplements, and meaning Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing. SPONSORS: Puori | Head to http://puori.com/dave for 20% off, including subscriptions. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Stephen's Website: https://www.ith.cam.ac.uk/staff/stephen-cave • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:09 Intro • 01:39 Life Extension Challenges • 02:05 Boredom and Mental Health • 04:28 Immortality vs. Enlightenment • 06:21 Death’s Role in Civilization • 09:06 Life Stages and Aging • 10:41 Global Immortality Narratives • 15:50 Personal Takes on Immortality • 20:46 Biohacking and Longevity • 28:43 Transhumanism Today • 31:00 Techno-Utopianism and Happiness • 32:20 Wealth and Fulfillment • 32:54 Purpose and Meaning • 34:00 Legacy and Death • 36:33 Near-Death and Mortality • 37:52 Time and Procrastination • 42:00 AI and Human Future • 45:56 Ethics of Life Extension • 50:35 Autonomy and Mortality • 52:35 Dangerous Ideas in Longevity • 55:53 Advice for the Young See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Fix What’s Making You Feel Old—From Joints to Mitochondria | Dr. Greg Kelly : 1296
    You feel stiff, tired, or older than you should—and this episode shows you how to reverse it. Learn how to fix joint pain, restore youthful movement, and upgrade your longevity by hacking the hidden causes of early aging like mitochondrial dysfunction, leaky gut, and chronic inflammation. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Gregory Kelly, SVP of Product Development at Qualia Life and a leading authority on functional medicine, nootropics, and anti-aging science. Dr. Kelly is a naturopathic physician, author of Shape Shift, former editor of Alternative Medicine Review, and a university instructor who’s published over 30 peer-reviewed papers and contributed to the Textbook of Natural Medicine. His deep expertise spans cellular regeneration, sleep optimization, metabolism, and the chronobiology of performance. They reveal why most joint pain has nothing to do with age, why your cartilage and synovial fluid become insulin resistant, and how biohacking your gut can dramatically improve joint function and brain optimization. You’ll discover how neuroplasticity, metabolism, sleep, and mobility are all tied to your ability to stay pain-free and high performing. Dr. Kelly also breaks down the science behind unconventional joint-support compounds like tamarind seed extract, eggshell membrane, L-carnitine, and senolytics. You’ll Learn: • Why joint pain is often a metabolic and mitochondrial issue, not aging • How zombie cells and gut toxins silently destroy your cartilage • What to take instead of glucosamine to actually rebuild your joints • Why most joint supplements fail and what new research says to use instead • How to enhance mobility using functional medicine and cutting-edge ingredients • How movement, inflammation, and brain health are deeply connected • Tools for real recovery without burnout using the smarter not harder method This channel explores how ketosis, fasting, cold therapy, and smarter not harder strategies affect movement, inflammation, and longevity. Dave also shares how Danger Coffee and his own supplement routines helped him reverse years of joint damage—and how you can do the same without drugs or surgery. This is essential listening for anyone serious about biohacking, human performance, and outsmarting the aging process at any age. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Qualia’s Website: www.qualialife.com/asprey15• Qualia's Instagram: https://www.instagram.com/qualialife/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:07 Joint Pain vs. Aging • 04:46 Gut-Joint Connection • 06:33 Diet’s Impact on Joints • 10:14 Smarter Joint Supplements • 19:15 Senescent Cells and Pain • 22:47 Collagen Breakdown • 24:21 Tamarind and Turmeric Benefits • 26:34 Inflammation Fixes • 29:39 Mobility and Movement • 38:26 Sleep and Joint Recovery • 42:52 Can You Reverse Joint Damage? • 44:48 Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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About The Human Upgrade: Biohacking for Longevity & Performance

For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
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