For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletp...
The Secret Molecule for Endless Energy | Dr. Andrew Salzman : 1253
Could a single molecule be the difference between vibrant longevity and early decline? Dr. Andrew Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor, Chief Medical Officer of Wonderfeel—joins Dave to reveal the real key to living longer, fighting disease, and maximizing your energy: NAD. This master molecule fuels your mitochondria, DNA repair, and cellular resilience, but here’s the catch—it plummets as you age. That means more fatigue, brain fog, inflammation, and higher risks of disease. But what if you could stop the decline and even reverse it? Dr. Salzman breaks down the game-changing science behind NAD, CD38, and cellular repair—and the fastest, most effective ways to optimize your levels for peak performance, health, and longevity. Get ready to rethink everything you thought you knew about aging, pharmaceuticals vs. supplements, and the radical new approach to living better, longer. What You’ll Learn: • The #1 reason your NAD is disappearing—and how to fix it • Why NAD is the missing link in energy, DNA repair, and disease prevention • The hidden enzyme (CD38) that’s sabotaging your longevity • How to supercharge mitochondria, optimize blood flow, and fight aging at the source • Why the supplement industry has it wrong—and the best way to boost NAD naturally • The shocking truth about the FDA, pharmaceuticals, and the future of anti-aging medicine Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Wonderfeel Instagram – https://www.instagram.com/getwonderfeel/ • Wonderfeel Supplement : https://getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=Dave&utm_medium=podcast • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: 00:00 Trailer 01:07 Introduction and Episode Overview 02:29 Meet Dr. Andrew Salzman 02:36 From Physician to Researcher 03:39 Pharmaceuticals vs. Nutritionals 04:17 The Role of NAD in Longevity 06:32 Challenges in Longevity Research 12:58 Understanding NAD and PARP 14:34 NAD’s Impact on Health 23:19 Gut Health and Longevity 27:43 Innovations in NAD Supplementation 41:27 Customer Feedback and Product Effectiveness 42:41 Surprising Benefits of NAD for Sexual Health 44:47 NAD and Vascular Health 48:46 NAD’s Role in Aging and Longevity 54:03 NAD and Lifestyle Choices 01:03:02 NAD and Cognitive Function 01:06:18 NAD and Exercise 01:13:42 NAD and Sleep 01:21:54 Final Thoughts on NAD and Longevity See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
--------
1:24:01
Fix Your Blood Sugar: The FASTEST Way to Burn Fat, Optimize Hormones & Reverse Disease | Benjamin Bikman : 1252
Welcome to the metabolism masterclass!Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about insulin resistance—the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman reveals how your hormones, not just your diet, control your metabolism and what you can do to reset it fast. From debunking diet myths to uncovering why some people can eat 400 grams of carbs and never gain fat (hint: it’s not what you think), this episode unpacks the real science of fat storage, energy, and optimal health. Get ready for mind-blowing insights, metabolic hacks, and a new way to think about food, fasting, and longevity. What You’ll Learn: • The #1 driver of insulin resistance—and why most doctors miss it • Why eating more fat (yes, really) could be the key to reversing metabolic dysfunction • How fasting, cold therapy, and red light impact your metabolism • The truth about carbs, seed oils, and why some people can’t gain fat • How to tell if insulin resistance is wrecking your energy & health Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Benjamin’s new book How Not To Get Sick : https://a.co/d/aADlMWv • Benjamin’s YouTube Page – https://www.youtube.com/@benbikman • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: -Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Timestamps: 00:00 Trailer 00:52 Introduction to Dr. Benjamin Bikman 02:20 The Battle Against Conventional Dietetics 04:12 Understanding Insulin Resistance 06:29 The Two Paths to Insulin Resistance 10:19 Fasting and Metabolic Health 14:11 Insulin and Cognitive Enhancement 18:16 Identifying Insulin Resistance 30:12 The Role of Insulin in Fat Storage 42:04 Understanding Glucose and Insulin Dynamics 42:26 The Role of Exercise in Glucose Regulation 42:54 AMPK and Muscle Contraction 45:21 Calories In, Calories Out Debate 46:15 The Myth of Calorie Counting 50:13 Ketosis and Metabolic Rate 51:14 Intermittent Fasting and Muscle Preservation 55:21 Insulin Resistance and Ketogenic Diets 01:02:04 Circadian Rhythm and Insulin Sensitivity 01:08:08 Environmental Toxins and Insulin Resistance 01:13:03 The Impact of Seed Oils on Insulin Resistance 01:19:22 Final Thoughts and Resources See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
--------
1:20:08
Rick Rubin: How to Hack Your Mind for Creative Breakthroughs : 1251
Most people wait for inspiration. But what if you could train your brain to create on demand? Rick Rubin has spent decades shaping the sound of legendary artists—Jay-Z, Johnny Cash, Metallica, and countless others—by tapping into the unseen forces of creativity. But what’s the secret behind his genius? In this must-listen episode, Rick sits down with Dave to explore the science and soul of creativity, revealing how meditation, mindfulness, biohacking, and unconventional thinking fuel artistic breakthroughs. From rewiring your brain with meditation to stacking biohacks for peak creative flow, Rick shares the techniques that have kept him at the top of the music industry for over 40 years. Dave and Rick go deep on the mental and physiological hacks that enhance creative performance, the surprising link between biohacking and artistry, and the rituals that keep Rick sharp, focused, and endlessly inspired. What You’ll Learn: • How Rick Rubin taps into creative flow—and how you can too • The surprising connection between meditation and peak artistic performance • Why biohacking isn’t just for longevity—it’s for creative mastery • Rick’s favorite tools for mental clarity, focus, and creative breakthroughs • The real secret behind working with the world’s biggest artists • How to cultivate an environment that fuels creativity Resources: • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Rick’s New Book The Creative Act: A way of Being: https://a.co/d/2bLbjeS • Rick’s Instagram: https://www.instagram.com/rickrubin/?hl=en • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: Omni-Biotic | Visit omnibioticlife.com/dave and use code DAVE20 for 20% off. BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. Timestamps: • 00:00 – Trailer • 00:51 – Intro to Rick Rubin • 02:51 – Rick’s Musical Journey • 03:06 – The Creative Process • 08:31 – Biohacking & Sensitivity • 13:46 – Meditation & Creativity • 19:37 – Rick’s Weight Loss Story • 29:21 – Eating Habits & Rhythm • 29:55 – Advanced Biohacking • 31:23 – Oxygen Therapy & Carbogen • 35:16 – Peptides & Longevity • 45:59 – Prayer, Gratitude & Performance • 51:03 – Reflections on Life & Mortality See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
--------
54:51
Tony Robbins on the Ultimate Secrets to Wealth, Mindset, and Success : 1250
What’s keeping you stuck in a scarcity mindset instead of stepping into abundance? What truly sets successful people apart from those who struggle? Tony Robbins has spent decades answering these questions—coaching billionaires, world leaders, elite athletes, and everyday people to master their money, mindset, and mission. In this all-time classic podcast, he shares the hard-hitting truths about financial freedom, why fear is your biggest enemy, and how to break free from the psychological traps that keep you stuck. Tony and Dave dive deep into the wealth-building playbook that the world’s top investors use (including Warren Buffett, Ray Dalio, and Paul Tudor Jones), plus the biohacks and routines that fuel Tony’s legendary stamina. From the real secret to compounding wealth to stem cell breakthroughs that could change human longevity, this episode will shift the way you think about money, health, and success. Most people dream of financial freedom, but few actually achieve it. What’s holding you back—and how can you break through? What You’ll Learn: • The biggest mistake people make with money (and how to avoid it) • The mindset of the ultra-wealthy—how top investors think differently • Why fear is your greatest enemy in investing and personal success • The three essential money buckets—security, growth, and dreams • Tony’s top biohacks for insane energy and peak performance • The real secret to happiness and fulfillment (it’s not what you think) Resources: • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Tony’s Website: https://www.tonyrobbins.com/ • Tony’s Instagram: https://www.instagram.com/tonyrobbins/?hl=en • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: -Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Timestamps: • 00:00 Intro • 00:50 Meet Tony Robbins • 02:18 Financial Wisdom & Motivation • 05:43 Psychology of Wealth • 10:10 Investment Strategies • 15:24 Balancing Money & Experiences • 21:21 Power of Giving • 30:06 Paying for College • 31:00 Commitment & Success • 31:53 Energy & Biohacks • 35:12 Cryotherapy & Inflammation • 38:54 Stem Cells & Regeneration • 41:59 Financial Freedom • 46:35 Wnt Pathway Breakthroughs • 52:35 Health & Longevity • 56:34 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
--------
56:49
Timbaland's Blueprint: How to Lose 130 Pounds, Beat Addiction, and Change Your Life TODAY! : 1249
From chart-topping hits to life-threatening lows—how did Timbaland go from producing for Jay-Z, Beyoncé, and Justin Timberlake to battling addiction and obesity? And more importantly, how did he take his life back? In this raw and revealing conversation, music icon Timbaland shares the blueprint behind his incredible transformation—how he broke free from opioid addiction, lost 130 pounds, and rewired his mindset for long-term success. He and Dave dive into the power of discipline, the dangers of quick fixes, and the hard truths about personal transformation. Timbaland opens up about the mental shift that saved his life, how he kicked a high-dose opioid habit cold turkey, and why his new “drug” of choice is something anyone can access. Most people want change, but few actually achieve it. What separates those who succeed from those who stay stuck? And how can you apply Timbaland’s hard-earned lessons to your own life? What You’ll Learn: • The #1 mindset shift that made weight loss & addiction recovery possible • Why self-discipline beats willpower—and how to build it like a muscle • The real reason most diets fail—and what actually works • The truth about opioid addiction and recovery—why most people never escape • How your daily habits shape your future—and how to change them fast • The shocking link between addiction, metabolism & long-term health • How Timbaland stayed clean without rehab—and why relapse wasn’t an option We’d like to extend our gratitude to Eudēmonia for providing the opportunity to record with Timbaland at their event. Eudēmonia, created by the founders of Wanderlust Festival, is a premier health and well-being summit. You can learn more about their initiatives and upcoming events here: https://wanderlust.com/ Resources: • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Timbaland’s Website: https://www.timbaland.com/ • Timbaland’s Instagram : https://www.instagram.com/timbaland/?hl=en • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: -STEMREGEN | | Head to https://www.stemregen.co/dave for 20% off your first order. -Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. Timestamps: • 00:00 Trailer • 00:00 Introduction to the Human Upgrade • 00:09 Timbaland on Passion and Energy • 00:42 Balancing Passion and Avoiding Burnout • 02:04 Dreams and Manifestations • 04:51 Overcoming Addiction • 05:59 The Role of God in Recovery • 09:28 Helping Others with Addiction • 14:00 Weight Loss and Health Transformation • 16:29 Trusting Your Body’s Signals • 18:45 Skepticism About Modern Products • 21:10 Exploring Longevity and Individual Health • 22:23 The Intersection of Music and Spirituality • 25:56 Understanding Synesthesia and Its Impact • 27:41 The Journey to Weight Loss and Fitness • 35:08 The Importance of Sleep and Health • 37:23 Final Thoughts and Reflections See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
Australia