Project 100 with Mark Bouris

Dr Stacy Sims is one of the world's leading exercise physiologists and nutrition scientists specialising in women's health, and she joins Project 100 to explain why the science women have been given is largely based on male data — and what that means for how women should actually train, eat, and protect their healthspan.
From the cellular differences between the sexes, to perimenopause, creatine, protein timing, Alzheimer's risk, and why sleep beats everything else — this is a conversation every woman (and the people who love them) needs to hear.
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Sebastian Oreb, better known as the Australian Strength Coach, has trained some of the world’s strongest athletes, including Hafþór Björnsson, Alex Simon, and elite professional athletes across multiple sports.
In this episode of Project 100, Sebastian breaks down the science of building muscle, explaining progressive overload, the best rep ranges for muscle growth, and why strength is one of the biggest predictors of healthy ageing.
We also cover:
Progressive overload explained simply
Compound vs isolation exercises
The best rep ranges for building muscle
How often you should train
Strength vs hypertrophy
Why muscle matters for longevity
Common gym mistakes that limit results
How to build muscle safely at any age
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Tim Piatowski is one of Australia's leading researchers on peptides and enhancement drugs, running the world's first steroid-checking trial and service.
In this conversation, we cover everything from what peptides actually are to the underground markets driving their use across Australia. Tim explains the science behind popular compounds like BPC-157 and GHK-Cu, the risks of unregulated products, and why Australia's regulatory approach is pushing people toward dangerous illicit markets. We also explore the potential for peptides in healthy ageing, injury recovery, and why our government's silence on this growing trend is creating more problems than solutions.
We speak about:
• What peptides are and how they work as signalling molecules
• BPC-157 for tissue healing and inflammation reduction
• GHK-Cu copper peptides for collagen synthesis and skin health
• Growth hormone releasing peptides like CJC-1295 and tesamorelin
• The contamination crisis in illicit enhancement drugs
• Legal pathways vs underground markets in Australia
• How peptides could transform healthy ageing and falls prevention
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Maria Andriano is one of Australia's leading strength coaches whose incredible physique at 54 proves that muscle truly is the fountain of youth.
In this episode, she reveals why building and maintaining muscle mass isn't just about aesthetics—it's your first line of defence against aging, illness, and frailty.
• Why women lose 10% muscle mass every decade after 30 and how to stop it
• The five compound movements every woman should master for longevity
• Post-workout nutrition timing that actually builds muscle (not just burns calories)
• How strength training during menopause can reverse hormonal decline
• Why the Ozempic generation is setting themselves up for metabolic disaster
• Maria's exact training split for maximum muscle gain with minimal gym time
• The truth about why most people plateau after years of training

All content is for informational purposes only and is not medical advice.
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All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice.
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Professor Matthew Kiernan is CEO of Neura and one of the nation's leading neurologists tackling the growing dementia crisis.
Kiernan explores why dementia is now Australia's number one cause of death, the modifiable risk factors that could prevent 45% of cases, and the groundbreaking monoclonal antibody treatments now available for Alzheimer's disease.
Kiernan explains how the Western Pacific region carries 60% of the world's dementia burden and why researchers are racing to develop blood biomarkers that could detect brain diseases decades before symptoms appear. We also get into:
• Why dementia has overtaken heart disease as Australia's leading killer
• The role of vascular health in brain function and cognitive decline
• Blood biomarkers coming within five years for early detection
• Monoclonal antibody treatments for Alzheimer's now available in Australia
• The connection between contact sports, head injuries and neurodegeneration
• How GLP-1 medications are showing promise for brain health
• Sleep's critical role in clearing toxic proteins from the brain

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