Project 100 with Mark Bouris

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice.
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Lucas Aoun is a naturopath and men's health researcher with a Bachelor of Health Science whose work on natural testosterone optimisation gained the attention of Andrew Huberman. In this episode, he walks through the full hormone production pathway from the hypothalamus to the testes, explains which blood markers most GPs overlook, and outlines the lifestyle, nutrition, and supplementation strategies he has used to bring his own testosterone to near-1,000 nanograms per deciliter naturally. The conversation also covers structural causes of low testosterone, the role of HBOT and sleep in hormone health, and when TRT becomes the appropriate next step.
Check out Lucas's stack here: https://www.inb4supps.com/products/peak-t
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Most people think longevity is about diet and supplements. Alexis Fernandez, cognitive neuroscientist, says the real killers are chronic stress, isolation, and outsourcing your brain to your phone. In this episode of Project 100, Mark Bouris sits down with Alexis to unpack what the science on centenarians actually shows — and it's simpler, and more confronting, than most people want to hear. From cortisol dysregulation to synaptic pruning to why resistance training is the best thing you can do for your brain, this conversation will change how you think about what it means to age well.
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Most people taking supplements are wasting their money — not because supplements don't work, but because what they're swallowing never actually reaches the cells that need it. Bioavailability scientist George Kokkinis has spent 30 years at the intersection of chemistry, regulation, and human performance, and what he shares in this episode will change how you read every supplement label. From vitamin D3 and NMN to berberine, CoQ10, and omega-3s, we break down what's actually getting absorbed, what's heading straight to the toilet, and what to look for before you spend another dollar. This is the supplement conversation nobody in the industry wants you to have.
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In this episode of Project 100, I sit down with one of Australia's leading cardiothoracic surgeons to understand what's actually happening inside your heart, what your cholesterol numbers really mean, and why the gap between men and women in heart disease outcomes is more serious than most people realise. This is the conversation that will change how you think about what you're doing to your body right now — not in 30 years' time.
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Dr Stacy Sims is one of the world's leading exercise physiologists and nutrition scientists specialising in women's health, and she joins Project 100 to explain why the science women have been given is largely based on male data — and what that means for how women should actually train, eat, and protect their healthspan.
From the cellular differences between the sexes, to perimenopause, creatine, protein timing, Alzheimer's risk, and why sleep beats everything else — this is a conversation every woman (and the people who love them) needs to hear.
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