84. Dr. Nick Norwitz: Why 'Evidence-Based' Medicine Fails Most People (And What to Do Instead)
The top 10 grossing drugs only help 1 in 4 to 1 in 25 people who take them. Yet they're still considered "evidence-based" and prescribed to millions. In this episode of Extend, I talk with Dr. Nick Norwitz, who reveals why you can't rely on population averages to fix your individual health problems. We explore why the medical system isn't designed to figure out what makes you unique, why "calories in, calories out" fails as a biological model, and how to become your own health scientist using the N=1 approach. We also discuss practical strategies for experimenting with your own biology, from testing ketogenic approaches to understanding why your results might be completely different from everyone else's. Dr. Nick Norwitz is a Harvard-trained MD/PhD who transformed his own health using metabolic interventions after conventional medicine failed him. He's known for his extreme self-experiments and scientific approach to personalized health optimization. We Also Discuss: Why Most "Evidence-Based" Treatments Don't Work for You The N=1 Approach: Becoming Your Own Health Scientist Why Population Averages Can't Predict Individual Results The Calorie Counting Myth That's Keeping You Stuck Ketogenic Diets: When They Work (And When They Don't) How to Design Your Own Health Experiments Why Bio-Individuality Trumps One-Size-Fits-All Solutions Escaping the "Normal" Trap in Modern Medicine  Thank You To Our Sponsors: IM8: Try IM8 today with a 30-day money back guarantee. You can get 20% off your first order with code DRSHAH at https://im8health.com/discount/DRSHAH.  Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/  Learn more about Dr. Nick Norwitz: Website:https://www.nicknorwitz.com/ YouTube: https://www.youtube.com/@nicknorwitzMDPhD/featured Instagram: https://www.instagram.com/nicknorwitz/ Â
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83. Dr. Joel Kahn: Why Most Cardiologists Are Missing the Real Causes of Heart Disease
What if everything you've been told about preventing heart disease is only half the story? In this episode of Extend, I sit down with Dr. Joel Kahn, a pioneering preventive cardiologist who's spent decades challenging the traditional approach to cardiovascular medicine. We explore why the 1961 Framingham risk factors represent an incomplete picture of heart disease, and the hidden culprits damaging your blood vessels every day. We also dive into why a $100 calcium score should be as routine as a mammogram, how your cooking methods could be aging your arteries, and the surprising connection between erectile dysfunction and heart attacks. Dr. Joel Kahn is a preventive cardiologist, author, and founder of the Kahn Center for Cardiac Longevity. He is one of the few cardiologists advocating for plant-based nutrition and comprehensive lifestyle medicine. He's written multiple books including "The Whole Heart Solution" and hosts "Heart Doc VIP" podcast. We Also Discuss: Beyond Cholesterol: The 20+ Hidden Risk Factors Your Doctor Isn't Checking The $100 Test That Could Save Your Life (And Why Insurance Won't Cover It) Advanced Glycation End Products: How Your Barbecue Is Aging Your Arteries The Glycocalyx: Your Body's Secret Vascular Protection System Why Every Man with ED Needs a Calcium Score TMAO and the Dark Side of Choline Supplements Blood Pressure Devices That Work Without Pills The Trauma Surgeon with Perfect Arteries Despite Sky-High Cholesterol EECP Therapy: The NASA Technology Rebuilding Hearts Nitric Oxide: The Nobel Prize-Winning Molecule You're Probably Destroying ApoB vs. LDL: The One Number That Matters Most Why Listerine Might Be Sabotaging Your Blood Pressure Thank You for Our Sponsors: NextHealth: Your destination for cutting-edge health optimization—from IV therapy to hormone balancing. Explore at https://www.next-health.com/  Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/  Learn more about Dr. Joel Kahn: Website: https://www.drjoelkahn.com/ Instagram: @drjkahnÂ
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82. Dr. Amy Shah: The Real Reason Women Lose Strength in Perimenopause (And How to Get It Back)
Why can't you open that jar anymore? Why does getting up from a chair feel harder than it used to? In this episode of Extend, I sit down with Dr. Amy Shah to explore the strength crisis happening to women in perimenopause. We dive into the simple tests that reveal where you're losing ground—and why most women are shocked by their results. We also share the exercise formula that actually works for perimenopausal women, honing in on the key fact that it has to be movement you enjoy, because sustainability beats intensity every time. Dr. Amy Shah is a double board-certified physician specializing in allergy/immunology and internal medicine, and author of I'm So Effing Tired. She's a leading voice in women's health, focusing on the intersection of hormones, gut health, and metabolism. We Also Discuss: The Grip Strength Test That Predicts Your Longevity (Most Women Fail) The Sit-to-Stand Test: Your Lower Body Strength Report Card Exercise Snacks: Why 10 Squats Every Hour Beats a 30-Minute Walk The Weighted Vest Mistake That's Wasting Your Time Why Jumping on a Trampoline Builds Stronger Bones Than Running Intermittent Fasting for Women: Why Daily Fasting Backfires Thank You To Our Sponsors: IM8: Try IM8 today with a 30-day money back guarantee. You can get 20% off your first order with code DRSHAH at https://im8health.com/discount/DRSHAH.  Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/  Learn more about Dr. Amy Shah: Website:https://amymdwellness.com/ Book: I’m So Effing TiredX: https://x.com/amyshahmd Â
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81. Dr. Zain Kassam: How Your Gut Bacteria Control Your Brain, Weight, and Longevity
What if I told you there's an organ in your body with more cells than the Milky Way has stars—and most doctors barely think about it? In this episode of Extend, I sit down with Dr. Zain Kassam, a gastroenterologist turned microbiome researcher who's pioneering how we understand the trillions of organisms living in and on us. We dive into why your gut bacteria aren't just bystanders—they're actively producing molecules that affect your mood, metabolism, immune system, and even longevity. We also explore the gut-brain connection, why not all probiotics are created equal, and how the microbiome influences everything from depression to skin health. Dr. Zain Kassam is a gastroenterologist, microbiome researcher, and Chief Medical Officer at Seed Health. He trained at McMaster University, Harvard, and MIT, where he pioneered clinical applications of microbiome science. He's led groundbreaking research on fecal transplants and develops evidence-based probiotic therapies.  We Also Discuss: The Microbiome Revolution: From Forgotten to Life-Saving Why Your Gut Has More Cells Than the Milky Way Has Stars How Gut Bacteria Control Your Brain and Mood The Butyrate Connection: Your Microbiome's Master Molecule Why Most Probiotics Are Marketing Hype (And How to Choose Better) The 4D Framework: Diversity, Delivery, Do-Gooders, and Data Microbiome Testing: Crystal Ball or Expensive Guesswork? From C. Diff to Cancer: When Gut Health Becomes Life or Death The GLP-1 Secret: How Your Gut Makes Its Own Ozempic Post-Antibiotic Recovery: Rebuilding After the Nuclear Bomb  Thank You for Our Sponsors: Pendulum: Use code DARSHAN or use the link https://pendulumlife.com/discount/DARSHAN to get 20% off  IM8: Try IM8 today with a 30-day money back guarantee. You can get 20% off your first order with code DRSHAH at https://im8health.com/discount/DRSHAH.  Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/   Learn more about Dr. Zain Kassam: X: https://x.com/DrZainSays/ Instagram: https://www.instagram.com/seed/ Get 25% off DS-01 with code EXTEND25 at Seed.com Â
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80. Dr. Nayan Patel: Your Cells Are Drowning (And One Molecule Can Save Them)
Oxidative stress. Toxin overload. Immune dysfunction. These aren't separate problems—they're all symptoms of your body working overtime on one exhausting job. In this episode of Extend, I sit down with Dr. Nayan Patel, a pharmacist who's dedicated his career to understanding glutathione—the molecule your body produces more than any other. We break down the three proven ways glutathione protects you, why IV and oral supplements have been failing for decades, and the gene mutations that leave 20% of people unable to benefit from traditional glutathione therapy. Most importantly, we discuss the stable glutathione breakthrough that's helping doctors reverse decades of brain fog in minutes. Nayan Patel, Pharm.D, is a pioneering pharmacist and researcher who discovered the first stable form of glutathione in 2007. His 25-year journey to unlock this master antioxidant has led to revolutionary insights about aging, detoxification, and immune function. We Also Discuss: Why Your Body's #1 Job Is Slowly Killing You (And How to Take It Over) The 100+ Daily Toxins Your Liver Must Process (You Can't Avoid Them) Glutathione's Triple Threat: Antioxidant, Detox, and Immune Power Why IV Glutathione Fails: The Shocking Truth About What Really Happens The Gene Factor: 20% of People Can't Use Traditional Glutathione (Are You One?) From Brain Fog to Clarity: Why Some See Results in 5 Minutes Thank You To Our Sponsors: Timeline: Upgrade your energy from within! MitoPure by Timeline helps power up your cells, supporting muscle strength, mental clarity, and overall vitality. Stay active, sharp, and strong at any age! Claim 10% off your first order now at timeline.com/DrShah IM8: Try IM8 today with a 30-day money back guarantee. You can get 20% off your first order with code DRSHAH at https://im8health.com/discount/DRSHAH.  Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/  Learn more about Nayan Patel, Pharm.D: Website:https://aurowellness.com/ Instagram: @aurowellness Book: https://aurowellness.com/glutathione-revolution/Â
Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan.
Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results.
That's why this podcast is all about cutting through the noise on how to turn back the aging clock.
I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health.
Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.
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