102. Max Lugavere: How to Prevent Alzheimer's 30 Years Before Symptoms
What if the biggest threat to your brain health isn't genetics, but the environment you're living in? In this episode of Extend, Max Lugavere joins me to share how environmental toxins, metabolic dysfunction, and dietary choices are driving the explosion of neurodegenerative diseases. We dive into why Alzheimer's begins 30-40 years before diagnosis, and the specific lifestyle interventions that can dramatically reduce your risk. From the dangers of golf course proximity to the surprising role of mouthwash in hypertension, this conversation challenges everything you thought you knew about protecting your brain. Max Lugavere is a health and science journalist, filmmaker, and bestselling author of "Genius Foods" and "The Genius Life." His documentary "Little Empty Boxes" chronicles his mother's battle with Lewy body dementia and explores the preventable nature of cognitive decline. Max has become one of the leading voices in brain health optimization. We Also Discuss: 08:02 - Why Neurodegenerative Diseases Begin 30 Years Before Symptoms 12:53 - Different Types of Dementia and Movement Disorders Explained 14:24 - Environmental Toxins Linked to Parkinson's Disease 16:03 - How Living Near Golf Courses Doubles Parkinson's Risk 31:04 - How One Gram of Pancreatic Fat Loss Restores Insulin Sensitivity 35:21 - Fasting Insulin: The Biomarker That Predicts Alzheimer's Early 37:12 - The Role of Ketogenic Diets in Brain Energy Metabolism 51:19 - How 20 Grams of Creatine Improved Cognition in Alzheimer's Patients 57:38 - The Truth About Seed Oils vs. Extra Virgin Olive Oil 1:09:04 - Omega-3s and the 50% Alzheimer's Risk Reduction 1:13:23 - Why Antiseptic Mouthwash May Raise Blood Pressure  Thank You for Our Sponsors: Timeline: Go to timeline.com/drshah to get 20% off your order. Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ https://www.instagram.com/nexthealth/ Instagram: https://www.instagram.com/darshanshahmd/  Learn more about Max Lugavere: Instagram: @maxlugavere Website: https://www.maxlugavere.com/ Â
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101. Dr. Mariza Snyder: Why 80% of Perimenopause Symptoms Are Brain Related and Doctors Keep Missing It
Did you know, 80% of perimenopause symptoms are brain-related, but it takes 4-6 doctor visits to get a diagnosis? In this episode of Extend, Dr. Mariza Snyder reveals why perimenopause has been medicine's best-kept secret and how women can reclaim their health during this critical transition. We discuss why perimenopause is called "the silent shift," the protective power of hormone replacement therapy, and why suffering through this transition is completely optional. Dr. Mariza also shares her personal hormone protocol and why she believes women deserve the gold standard of care during this pivotal decade. Dr. Mariza Snyder is a hormone and metabolic health expert specializing in perimenopause and menopause care. She's the author of "The Perimenopause Revolution" and host of the "Energized with Dr. Mariza" podcast. With nearly 15 years of experience helping women navigate hormonal transitions, she advocates for preventative hormone replacement therapy and comprehensive biomarker tracking. We Also Discuss: 04:54 - Why 80% of Perimenopause Symptoms Are Brain-Related 07:49 - The "Silent Shift" That Happens Years Before Missing Periods 11:21 - Why Standard Blood Work Keeps Women Suffering in Silence 12:57 - The Biomarkers Every Woman Should Track Starting at 35 30:49 - What Women Can Do to Start Managing Perimenopause 39:45 - How Hormone Replacement Therapy Acts as Your "Protective Shield" 55:21 - The Truth About Breast Cancer Risk and HRT 1:01:21 - Advanced Cancer Screening Strategies for Women 1:05:24 - Why Sleep Consistency Can Change Your Life in 10 Days 1:06:23 - The Mindset Shifts That Make Perimenopause Empowering  Thank You for Our Sponsors: NextHealth: Your destination for cutting-edge health optimization from IV therapy to hormone balancing. Explore at https://www.next-health.com/ Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ https://www.instagram.com/nexthealth/ Instagram: https://www.instagram.com/darshanshahmd/  Learn more about Dr. Mariza Snyder: Instagram: https://www.instagram.com/drmariza/ Website: https://drmariza.com/ Â
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100. Laird Hamilton & Gabby Reece: Why Avoiding Discomfort Is Ruining Your Health
What does it take to translate athletic excellence into mastery of life, relationships, and business? In this episode of Extend, legendary big wave surfer Laird Hamilton and pro volleyball champion Gabby Reece join me to share the mindsets and practices that have sustained their 30-year relationship and individual success. We discuss why "getting tired" is essential for health and how they've built a thriving business around authentic products. We also discuss the simple daily rituals that matter more than complex optimization protocols. Laird Hamilton is a pioneer of big wave surfing and hydrofoiling, while Gabby Reece dominated professional volleyball before becoming a wellness advocate. Together, they created XPT (Extreme Performance Training) and co-founded Laird Superfood, a publicly-traded company focused on functional nutrition. We Also Discuss: Why "Getting Tired" Makes Food Taste Better and Improves Sleep Quality The Art of Comfortable Confrontation in Marriage and Business Why Observing Nature Is Medicine for Modern Stress The Decision Fatigue Trap That's Sabotaging Your Day Before 9 AM Why They Choose Their Suffering Instead of Letting Life Choose for Them Thank You for Our Sponsors: Vitaboom: For supplements you can trust and wellness solutions tailored to your health, visit https://vitaboom.com/ Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ @nexthealth Instagram: @darshanshahmd  Learn more about Gabby Reece and Laird Hamilton: Instagram: @airdhamilton @gabbyreece
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99. Dr. Jess Peatross: The Hidden Toxins Making You Sick + The Kill-Bind-Sweat Detox Method
What happens when a traditional doctor discovers that everything they were taught in medical school is keeping patients sick? In this episode of Extend, Dr. Jess Peatross joins me to discuss the hidden toxins that could be behind your symptoms. We discuss why 95% of people don't get enough fiber, the "kill-bind-sweat" protocol that's gone viral for detoxification, and why your "normal" blood work might be missing the real problem. Dr. Jess also shares her shocking experience losing her medical license for questioning vaccine protocols. Dr. Jess Peatross is a traditionally trained internal medicine physician who worked as a hospitalist for seven years before transitioning to functional medicine. She's the founder of Wellness Plus, an online platform helping people detox safely from environmental toxins, and Aegis Formulas supplement company. She specializes in treating complex chronic conditions involving mold toxicity, parasites, heavy metals, and environmental toxin exposure. We Also Discuss: Why Traditional Blood Work Misses 95% of Chronic Disease Causes How the "Kill-Bind-Sweat" Protocol Detoxes Your Body Safely The Vibrant Total Tox Test That Reveals Hidden Environmental Toxins Why Parasites Are More Common in America Than You Think How Modern Energy-Efficient Homes Create Perfect Mold Conditions The MTHFR and COMT Genes That Determine Your Detox Ability Why 95% of People Are Fiber-Deficient and How It Drives Disease The Microscope Method vs. Modern Parasite Testing Limitations How to Test Your Home Environment for Hidden Toxin Exposure Why You Must Fix Your Nervous System Before Any Detox Protocol  Thank You for Our Sponsors: NextHealth: Your destination for cutting-edge health optimization from IV therapy to hormone balancing. Explore at https://www.next-health.com/ Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ @nexthealth Instagram: https://www.instagram.com/darshanshahmd/  Learn more about Dr. Jess Peatross: Instagram: @dr.jess.md Website: https://drjessmd.com/
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98. Dr. Dawn Mussallem: Why 75% of Cancers Are Actually Preventable + The Evidence-Based Protocol
What happens when a medical student gets diagnosed with stage 4 cancer and given three months to live? In this episode of Extend, Dr. Dawn Mussallem joins me to share her incredible journey from near-death to becoming a leading integrative oncologist at Mayo Clinic, proving that lifestyle interventions can dramatically improve cancer outcomes. We discuss how 42% of cancers are preventable through lifestyle changes, why ultra-processed foods increase cancer risk by 16%, and the shocking truth about soy and breast cancer. We also share her evidence-based protocol combining conventional treatments with integrative modalities. Dr. Dawn Mussallem is a double board-certified physician in Internal Medicine and Lifestyle Medicine at Mayo Clinic, where she designed the integrative breast oncology program. A cancer survivor who received a heart transplant in 2021, she combines personal experience with rigorous science to help patients optimize their health during and after cancer treatment. We Also Discuss: Why 75% of Cancers Are Caused by Lifestyle Factors (Not Genetics) How Ultra-Processed Foods Increase Cancer Death Risk by 30% The Shocking Truth About Soy and Breast Cancer (It's Actually Protective) Why Half Your Plate Should Be Vegetables or Fruits at Every Meal The 30 Diverse Plant Foods Per Week Rule for Optimal Gut Health Low-Dose Naltrexone's Immune-Boosting Effects for Cancer Patients Why Exercise During Chemotherapy Actually Improves Outcomes How Fermented Foods Support Cancer Prevention and Treatment The Mayo Clinic Protocol for Maintaining Vitality During Treatment Why Skipping Breakfast Increases All-Cause Mortality Risk  Thank You for Our Sponsors: Try IM8 today with a 30-day money back guarantee. You can get 10% off your first order with code DRSHAH at https://im8health.com/discount/DRSHAH. Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ https://www.instagram.com/nexthealth/ Instagram: https://www.instagram.com/darshanshahmd/  Learn more about Dr. Dawn Mussallem: Instagram: https://www.instagram.com/drdawnmussallem/?hl=en LinkedIn: linkedin.com/in/dawn-mussallem-do-dipablm-2b360b57 Â
Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan.
Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results.
That's why this podcast is all about cutting through the noise on how to turn back the aging clock.
I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health.
Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.
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