Bloody Minded

What’s a CHIP and why is it so delicious? Why do we still abbreviate myeodysplastic neoplasm to MDS? How did Bashar get his hands on the Necronomicon? These are questions that every budding haematologist asks themselves at some point and we will answer at least some of them here! Join us today for a birds-eye overview of the myeloid family of disorders before we dig into them more over the coming weeks. 
TIMESTAMPS
0:57 - Does anyone know a good priest?  
3:17 - Myeloid conditions in bucket form  
5:30 - Acute vs chronic in haematological diseases  
7:35 - Myeloid precursor lesions  
10:33 - Myeloproliferative neoplasms  
15:23 - Myelodysplastic syndromes  
18:50 - MDS/MPN Overlap Syndromes  
22:29 - Mastocytosis  
26:02 - Acute myeloid leukaemia  
28:23 - (Acute promyelocytic leukaemia)  
29:36 - Histiocytic/dendritic cell disorders  
31:14 - Take Home Messages
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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Hi-ho, Hi-ho, it's off the myeloid factory we go. Grab your fastest belt, a spare inserter and all the iron plates you can get your hands on as the Bloody Minded Crew embark on their nerdiest references yet and learn all about the basic science behind myelopoiesis. You’d better hop on a train, because the only main bus here goes straight from the marrow out to the periphery carrying all sorts of myeloid cells. And some blue circuits. 
0:52 - New year same us
2:44 - Season overview: myeloid time, baby!
5:15 - What is the myeloid compartment?
7:29 - Myelopoiesis
12:49 - Stem cell destiny... does free will exist?
14:28 - The myeloid progenitor
16:30 - Red cells and platelets
17:46 - White cell maturation
19:34 - Hormonal control of myelopoiesis
21:25 - Historical diversion into GCSF
23:19 - Clinical use of stimulating factors
26:39 - GCSF Bone Pain
28:15 - Emergency Myelopoiesis
30:08 - Wrap Up
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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

So you’ve been asked to start a DOAC? How is that different from a NOAC? Is there a difference? Which one should you start? Is warfarin a WOAC? How do I initiate these drugs? Why is the dose weird at the beginning? Do I need to check my dose is appropriate? 
If oral anticoagulation has you discombobulated you are in the right place!! In part II on the practical management of anticoagulation we are here to clarify all your questions on the most common types of oral anticoagulation you will come across as a junior doctor on the wards.
Timestamps
1:44 - Part I Recap and Part II Introduction
3:44 - History of Warfarin
8:37 - Mechanism of Warfarin
13:01 - Monitoring Warfarin
16:52 - Why Warfarin? and warfarin tips
21:40 - Warfarin reversal
31:05 - Warfarin Skin Necrosis & Drug Interactions
36:08 - Warfarin in Special Circumstances
40:25 - DOACs Intro
41:12 - Dabigatran
48:25 - Anti-Xa Agents (Rivaroxaban / Apixaban)
52:38 - Anti-Xa Monitoring (or not)
59:28 - DOACS - Special Circumstances
1:05:58 - Wrapup

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Does my blood look fat in this?
Does the idea of heparin being a fraction make you wish you listened harder in maths? What is unfractionated heparin? Why are haematologists so judgmental and prefer their anticoagulation low molecular weight? Why does haematology frown when you use the term “blood thinners” ?!?!
If injectable or parenteral anticoagulation feels confusing you have come to the right place! Today we look at unfractionated heparin and low molecular weight heparin,  practical things to think about and how to manage these drugs safely on the wards and beyond 
NB We’re going to leave the advanced injectables like Fonda/Danaparoid/Bivalirudin to a dedicated alternative, probably HITTS themed episode if you’re looking for these drugs

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Twas the night before Christmas, and all through the house, not a creature was stirring, particularly not a missing coagulation factor. Welcome to a very special present all wrapped and delivered by Santa and his Christmas elves and stuffed in your podcast queue in time to drive off for the holidays. Join Cale, a very dusty Bashar, Nick and Santa as we learn a little bit about Christmas Disease. We swear his jacket was that colour before we messed with his haemostatic pathways… CONTENT WARNING: Singing
TIMESTAMPS
00:55 - Pure unbridled musical talent 
03:34 - Intro to Christmas Disease/Haemophilia B
04:58 - History of Haemophilia B
14:01 - Presentation of Haemophilia B
18:25 - Haemophilia B Leyden
22:49 - Coagulation studies in Haemophilia B
26:20 - Treating Haemophilia B
28:12 - Where does factor replacement come from?
31:57 - Inhibitors
33:48 - Gene therapy
37:27 - Take home messages

Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au