Lifespan with Dr. David Sinclair

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at https://lifespan.com.

Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.

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Could an amino acid sweet enough to replace sugar also help us live longer? In this episode, David and Matt explore Glycine, one of life’s simplest building blocks, and why it’s attracting attention in aging research. From building collagen to blood sugar control, heart health, memory, and recovery after stroke, its potential reaches surprisingly far. They unpack studies linking glycine to multiple hallmarks of aging and longer lifespans in animal models and ask what it would take to show these benefits in humans.

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Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.

Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).

If you’d like to learn more or try these tools:

○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN

○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN

○ Withings: Get 10% off smart health devices at https://withings.com/lifespan

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Legal & Medical Disclaimers

The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.

You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.

The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.

Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.

From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.

Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.

The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at https://lifespan.com.

Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.

__________________________________________

Could an amino acid sweet enough to replace sugar also help us live longer? In this episode, David and Matt explore Glycine, one of life’s simplest building blocks, and why it’s attracting attention in aging research. From building collagen to blood sugar control, heart health, memory, and recovery after stroke, its potential reaches surprisingly far. They unpack studies linking glycine to multiple hallmarks of aging and longer lifespans in animal models and ask what it would take to show these benefits in humans.

__________________________________________

Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.

Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).

If you’d like to learn more or try these tools:

○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN

○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN

○ Withings: Get 10% off smart health devices at https://withings.com/lifespan

__________________________________________

Legal & Medical Disclaimers

The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.

You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.

The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.

Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.

From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.

Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.

The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at https://lifespan.com.

Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.

__________________________________________

This Lifespan episode explores how what we eat shapes how we age - from inflammation and blood sugar to the trillions of microbes living in our gut. Dr. Sinclair explains how diet affects key biological processes tied to metabolism, health, and longevity.

Dr. Sinclair breaks down what sugar does inside the body, including glycation - the process by which sugar attaches to proteins and disrupts their function. The conversation also explores why inflammation rises with age, how the gut microbiome changes over time, and why our ability to sense and respond to nutrients can decline as we get older.

Most importantly, Dr. Sinclair explains what we can do about it - from reducing dietary drivers of inflammation and excess sugar to supporting gut health and the nutrient-sensing pathways linked to longevity.

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Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.

Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).

If you’d like to learn more or try these tools:

○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN

○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN

○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN

__________________________________________

Legal & Medical Disclaimers

The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.

You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.

The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.

Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.

From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.

Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.

The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at https://lifespan.com.

Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.
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In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. - Professor of Genetics at Harvard Medical School and longevity scientist - and co-host Matthew LaPlante explore why we age, how aging begins long before its visible signs appear, and what we can do to slow aspects of cellular aging.

They break down key drivers - or “hallmarks” - of aging, including mitochondrial dysfunction, stem cell exhaustion, and declining communication between cells, and explain how these changes can affect energy, inflammation, and the body’s ability to repair itself.

They also explore practical strategies including exercise, cold exposure, and molecules such as berberine, curcumin, metformin, and resveratrol, alongside emerging research into mitochondrial replacement and stem cells.

Along the way, they tackle intriguing questions: When does biological aging begin? Why can identical twins age at different rates? Why does energy decline with age? And what can we do today to stay healthier for longer?
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Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.

Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).

If you’d like to learn more or try these tools:

○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN

○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN

○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN
__________________________________________

Legal & Medical Disclaimers

The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.

You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.

The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.

Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.

From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.

Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.

The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives.

We’re building the world’s largest longevity community: Join us at https://lifespan.com.

Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks.

__________________________________________

This episode explores why humans are biologically built to move and what happens to the aging process when we don’t.

Drawing on evolutionary biology and the latest research, Dr. Sinclair traces physical activity back millions of years, explaining how humans evolved for endurance, why modern sedentary life creates a profound mismatch with our biology, and how exercise activates ancient cellular pathways involved in repair, resilience, metabolism, and longevity.

Dr. Sinclair breaks down what happens inside the body when we exercise, including the molecular responses that help us adapt to stress and influence the brain, immune system, metabolism, cardiovascular health, and even the way our cells age.

He also tackles some of the biggest questions in exercise science: Can exercise offset sitting all day? Do we compensate for calories burned during exercise? Why did humans evolve such extraordinary endurance? And could exercising with others provide benefits beyond physical fitness?

From our evolutionary past to the molecular machinery inside our cells, this episode reveals why movement is so deeply embedded in human biology – and why staying active may be one of the most powerful ways to keep that biology working as we age.

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Partners of the Lifespan show help us keep this program freely available as an educational resource while also supporting medical research. We only collaborate with partners whose products are grounded in science and that our team has personally used for years.

Our selected partners make it convenient for the Lifespan audience to access the tools and technologies featured in this episode - from exogenous fuel for neurons (Ketone-IQ), to wearables that track recovery, strain, and sleep (WHOOP), to smart devices that measure key health metrics such as visceral fat and muscle mass (Withings).

If you’d like to learn more or try these tools:

○ Ketone-IQ: Get 30% off your first monthly order at https://ketone.com/lifespan or with code LIFESPAN

○ WHOOP: Get a free WHOOP band and one month of membership at https://join.whoop.com/LIFESPAN or with code LIFESPAN

○ Withings: Get 10% off smart health devices at https://withings.com/lifespan or with code LIFESPAN
__________________________________________

Legal & Medical Disclaimers

The Lifespan show and all related content are provided for informational and educational purposes only and are not intended as medical advice, diagnosis, or treatment. Nothing presented should be interpreted as a recommendation to diagnose, treat, cure, or prevent any disease or medical condition. This content is not a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.

You should always consult with a licensed physician or other qualified healthcare professional before making decisions about your health, including starting, stopping, or modifying any treatment, supplement, diet, or exercise program.

The information shared reflects the views and opinions of the host and guests and is based on the scientific literature, their experience and expertise, and general wellness principles. Listening to or engaging with Lifespan content does not establish a doctor–patient or clinical relationship.

Health and longevity outcomes can vary significantly between individuals. Any references to studies, interventions, products, or protocols are not guarantees of specific results, and individual responses may differ.

From time to time, Lifespan may discuss or partner with third-party products or services. These references are provided for informational purposes only and should not be considered medical recommendations or endorsements of efficacy for any individual.

Lifespan Foundation is an independent 501(c)(3) non-profit organization whose mission is to support medical research.

The views expressed by Dr. David Sinclair, A.O., Ph.D., are his own and do not represent those of Harvard University, Harvard Medical School, or any affiliated institutions.