Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

I’m thrilled to reconnect with microbiome expert Kiran Krishnan today. Kiran co-founded Just Thrive and previously served as Chief Scientific Officer at Microbiome Labs. He has more than 16 years of experience in the dietary supplement and nutrition industry, with postgraduate research experience in molecular biology and virology.

In today’s conversation, we take a deep dive into the science of spore-based probiotics, their ecological impact, how they interact with the existing gut microbiome, their potential to address dysbiosis, and why standard probiotics fail to survive stomach acid in meaningful numbers. We explore research on osteoarthritis, catabolism, and the gut-hormone connection, discussing how declining bacterial diversity may influence the metabolic and hormonal changes associated with perimenopause and menopause. Kiran explains the role of the pathobiome and endotoxemia, how the gut-brain axis can influence inflammation, and the importance of gut-barrier integrity, neurotransmitter production, and vagal nerve signaling in regulating the immune system. We also discuss the differences between fiber, resistant starch, polyphenols, fermented foods, prebiotics, and postbiotics, and Kiran shares his perspective on the carnivore diet, its potential impact on the microbiome, and key insights into SIBO.

Stay tuned for today’s fascinating and informative conversation with Kiran Krishnan.

IN THIS EPISODE, YOU WILL LEARN:

Kiran explains the science behind spore-based probiotics

Why spore-based probiotics can survive stomach acid better than many standard probiotics

How inflammation can inhibit the growth of beneficial gut bacteria

How bacterial diversity in the gut decreases during perimenopause and menopause

Why awareness of endotoxemia remains limited within the broader medical community

Kiran explains how the gut-brain axis helps the body respond to its environment

What prebiotics and postbiotics actually do

Why an inability to tolerate fiber may point to a problem with the underlying biology rather than the food itself

How SIBO and SIFO can be symptoms of a more complex underlying problem

Bio: Kiran Krishman, Ph.D.

Kiran is a research microbiologist and a health and wellness expert who aims to make complex information understandable to all. He has founded several successful health and supplement companies over the last 15 years, including co-founding and leading Microbiome Labs, a preeminent microbiome therapeutics-focused brand among healthcare professionals. He is currently a co-founder and partner in 3 other companies that aim to revolutionize wellness care. He has conducted and published several research studies in scientific journals, published chapters in scientific textbooks/references books, holds global patents, and is a sought-after speaker on human health and the microbiome.

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Purchase Cynthia’s book, The Menopause Gut.

Cynthia’s Intermittent Fasting Transformation Book

The Midlife Pause Supplement Line

Connect with Kiran Krishnan

The Biome Learning Center: Join Kiran’s circle community to download his free leaky gut guide and 5 pillars for building a resilient gut.

Welcome to the latest Midlife Minute.

Today, I answer some listener questions about bone health, osteoporosis, HRT, and the menopause transition.

Stay tuned to learn more about bone loss, bone health, and proactive ways to protect your bone mass.

IN THIS EPISODE, YOU WILL LEARN:

Bone density loss during perimenopause

Value of HRT for protecting bone mass during the menopause transition

If you’re using an estrogen patch and your estrogen levels are still low, what should you consider?

How women with osteoporosis can continue strength training with guidance from a licensed medical provider

What highly-active women who consistently under-fuel their bodies may experience

Conditions and medications that could contribute to low bone density

The value of DEXA scans and bone health markers

Bone loss may accelerate during menopause

How HRT for osteoporosis prevention differs from HRT for established osteoporosis

The benefit of AMH and FSH labs for identifying women who may benefit from earlier intervention

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Check out Cynthia’s website.

Submit your questions to support@cynthiathurlow.com

Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.

Purchase Cynthia’s book, The Menopause Gut.

Cynthia’s Intermittent Fasting Transformation Book

The Midlife Pause Supplement Line

I’m thrilled to reconnect with Roseann Capanna-Hodge, Ed.D., today. She's a licensed clinical psychologist, board-certified in neurofeedback, and mom of two neurodivergent children. She's also the author of the upcoming book, The Dysregulated Kid.

Today, we discuss how midlife women become stressed and how stress is an event and dysregulation is a physiological state. We also explore emotional regulation, hypervigilance, midlife’s invisible load, strategies to stimulate the vagus nerve, and ways to address both over- and under-stimulated behavior.

Stay tuned for today’s insightful and informative conversation with Roseann Capanna-Hodge. You’ll walk away with tangible strategies for yourself and your family members, too!

IN THIS EPISODE, YOU WILL LEARN:

How stress “creeps in” through everyday pressures and affects the nervous system

Why some coping strategies that worked earlier in life may become less effective or maladaptive amid midlife hormonal and neurological changes

The value of practicing belly breathing and other regulation strategies in “micro little bits” throughout the day

How emotional regulation can help change dysregulated patterns passed down through families.

How explaining regulation through science can reduce shame and help children become more receptive to these strategies.

Why caring for a dysregulated child can be especially triggering for parents with difficult childhoods or histories of dysregulated parenting

How women carrying an “invisible load” can find small openings to practice regulation strategies throughout the day

How nutrition can support emotional regulation and affect focus, motivation, irritability, anger, and hyperactivity

How using brief regulation practices, movement, breathing, touch, and daily routines can help manage chronic stress.

Why regulating the nervous system should come before, or support, other interventions

Bio:

Roseann Capanna-Hodge. Ed.D. is a leading expert in emotional and behavioral dysregulation with more than 30 years of experience helping families transform chaos into calm. As the creator of Regulation First Parenting® and the CALMS Dysregulation Protocol®, she bridges clinical science with everyday parenting so families can finally understand what’s really driving their child’s struggles.

Specializing in nervous system dysregulation, the root cause of challenges like ADHD, anxiety, OCD, mood disorders, and PANS/PANDAS, Roseann gives parents and professionals brain-based tools that create lasting change without blame, shame, or guesswork.

Through her bestselling books, upcoming book The Dysregulated Kid, and top 1% podcast, Dysregulated Kids, she has helped thousands of families support their child’s brain, behavior, and emotional well-being in practical, hopeful ways. Featured in The New York Times, Forbes, and Parents Magazine, Roseann is on a mission to bring Regulation First Parenting™ to every home so that children can thrive and families can finally feel calm again.

Connect with Cynthia Thurlow

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Check out Cynthia’s website.

Submit your questions to support@cynthiathurlow.com

Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.

Purchase Cynthia’s book, The Menopause Gut.

Cynthia’s Intermittent Fasting Transformation Book

The Midlife Pause Supplement Line

Connect with Roseann Capanna-Hodge, Ed.D

Website

Social media: @Dr Roseann

Order Roseann’s NEW book, The Dysregulated Kid.

I’m honored to reconnect with Dr. Felice Gersh today! She is a multi-award-winning physician with dual board certification in OB-GYN and Integrative Medicine. We connected once before in Episode 221, where we spoke about PCOS and metabolic health.

Today, Dr. Gersh joins me to dive into perimenopause and menopause. We discuss various issues surrounding the Women’s Health Initiative and talk about estrogen as a family of hormones, estrogen-mimicking chemicals, synthetic hormones, and oral contraceptives. We cover the importance of thyroid function, the pro-inflammatory state associated with estrogen loss in perimenopause and menopause, and the role of nutrition and exercise in metabolism. We also discuss lesser-known changes that occur in menopause, including changes in body odor, constipation, sarcopenia, osteoporosis, and vocal changes.

I plan to invite Dr. Gersh back to discuss women and mitochondrial health, and then again to talk about her latest book, Menopause: The Fifty Things You Need to Know.

Stay tuned to find out what menopause really is, and what it does to a woman’s metabolic system.

IN THIS EPISODE YOU WILL LEARN:

Dr. Gersh discusses the Women’s Health Initiative study and its devastating effects.

The difference between synthetic and bioidentical hormones.

How chronic diseases of aging can be delayed when hormones are incorporated along with other lifestyle refinements.

What do hormones do?

Why every immune cell in the body has receptors for vital hormones.

Menopause may not be defined by a specific moment in time.

Physiological changes that occur during the perimenopause years

How hormones can change the perimenopause paradigm entirely.

Perimenopause and sleep issues

Phytoestrogens - nature’s gift to women

Connect with Cynthia Thurlow

Follow on X, Instagram & LinkedIn

Check out Cynthia’s website.

Submit your questions to support@cynthiathurlow.com

Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.

Purchase Cynthia’s book, The Menopause Gut.

Cynthia’s Intermittent Fasting Transformation Book

The Midlife Pause Supplement Line

Connect with Dr. Felice Gersh

Website:⁠ Integrative Medical Group of Irvine⁠

Instagram⁠

Dr. Gersh’s books are available on ⁠Amazon⁠

Previous Episode Mentioned

⁠Episode 221 on PCOS with Dr. Felice Gersh⁠

Today, I’m honored to reconnect with fan favorite, Dr. Tom Dayspring. Dr. Dayspring is a fellow of both the American College of Physicians and the National Lipid Association, and is certified in internal medicine and clinical lipidology with extensive experience in perimenopause and menopause management. He has been a frequent contributor and educator at Everyday Wellness.

In this episode, we discuss labs that help to monitor changes in insulin resistance (specifically the LPIR score), the clinical practice limitations Dr. Dayspring believes stem from a lack of humility, and aspects of women’s medical histories that may indicate greater heart disease risk. We examine statin therapy and other treatment modalities, premature menopause and cardiovascular disease risks, Lp(a) as the primary inherited risk factor for heart disease, and current guidelines, treatment goals, and recommendations. Dr. Dayspring also shares his thoughts on estrogen patch shortages and oral estradiol therapy challenges with elevated triglycerides.

As always, this is an invaluable conversation with Dr. Tom Dayspring. Stay tuned for an upcoming podcast with Dr. Dayspring, where we'll focus on lipids and brain health.

IN THIS EPISODE, YOU WILL LEARN:

Lipoprotein changes and how they can reveal insulin resistance before fasting insulin or glucose begin to rise

Why someone can be insulin resistant while showing normal triglyceride levels

The importance of looking at a woman’s broader medical history to find potential cardiovascular risk signals

Why premature menopause and premature ovarian failure should be taken seriously as cardiovascular and long-term health risk factors

How Lp(a) is the most inherited risk factor for atherosclerotic heart disease across the population

Why women may benefit from repeat Lp(a) testing around the menopausal transition

What clinicians may address when Lp(a) is elevated, including other modifiable cardiovascular risk factors

Oral estrogen may have a beneficial effect on Lp(a).

How epidemiological evidence has linked endometriosis with heart disease

Why Dr. Dayspring recommends checking ApoB when triglycerides are elevated

Connect with Cynthia Thurlow

Follow on X, Instagram & LinkedIn

Check out Cynthia’s website.

Submit your questions to support@cynthiathurlow.com

Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.

Purchase Cynthia’s book, The Menopause Gut.

Cynthia’s Intermittent Fasting Transformation Book

The Midlife Pause Supplement Line

Connect with Dr. Tom Dayspring

On X (@DrLipid)

LinkedIn