All links here: https://hunterwilliamshealth.com/links
00:00 — Intro and why I'm doing these masterclasses
02:42 — What we're covering and the regulatory timeline
04:04 — The two users: weight loss vs longevity
05:30 — What Retatrutide actually does (the three receptors)
06:50 — Why the glucagon receptor makes Retatrutide different
07:54 — Weight loss trial data (1mg to 12mg)
10:50 — The longevity data: liver fat, ApoB, blood pressure
13:14 — Who the lean biohacker user is
13:50 — The titration playbook
15:32 — Once weekly vs split dosing
19:50 — Morning vs night injections
21:02 — How far to push the dose (why 8mg is the ceiling)
22:50 — How long to stay on and the regain problem
25:44 — Longevity maintenance protocol
26:34 — Lean user protocol
27:24 — Protein and training are non-negotiable
29:06 — Side effects and how to manage them
30:20 — The heart rate question and why I use taurine
32:00 — The weird skin sensitivity issue
33:48 — Pairing Retatrutide with testosterone
35:56 — Drug interactions (blood pressure, thyroid, insulin)
37:02 — Metrics that matter
38:42 — How to cycle off correctly
39:54 — The most common mistakes
40:42 — How to start, what to do if you plateau
43:04 — Should you switch from Tirzepatide?
45:28 — Combining Retatrutide with other peptides
46:50 — The Ten Commandments of Retatrutide use
47:50 — The bottom line
Today's episode is the first in a new format I'm rolling out. I'm working on a book where I cover one peptide at a time, one chapter at a time. Alongside that, I wanted to do a masterclass on each peptide and condense down everything I know into one place. First up is Retatrutide.
I cover what it actually does in your body, the two very different users that should be on it, and the dosing strategies that get debated to death online. We go through the weight loss data, the longevity data, and why I think 8 milligrams is the real ceiling for most people. I also break down once weekly versus split dosing, the heart rate question, the skin sensitivity issue, and why testosterone optimization has to come first.
If you want a definitive guide on Retatrutide, this is it. My goal is that you walk away with a framework you can actually use, whether it's on yourself, your coaching clients, or your patients.
Let me know what you think. I plan on doing many more of these on every peptide that matters.
⚠️ For research and entertainment purposes only. ⚠️
Australia