The Hunter Williams Podcast

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One of the most common questions I get is which peptides I actually hate. And honestly, it's a fair thing to ask. You're spending real money on these compounds, so you deserve to know which ones might not be worth it.
In this episode, I break down my five most overrated peptides. None of these are dangerous. Most have legitimate research behind them. They've just been surpassed by better compounds that cost about the same and work significantly better.
I cover AOD-9604 and why the clinical trials underwhelmed, GHRP-2 and GHRP-6 and the cortisol and hunger problems they create, HGH Frag 176-191 and why it's somehow worse than AOD, Sermorelin and why I think it persists despite better options being available, and oral 5-Amino-1MQ capsules versus the injectable form.
For each one, I share what I'd use instead. Tesamorelin, GLP-1 agonists, Ipamorelin with CJC-1295, and the injectable version of 5-Amino are all on the table.
This isn't a hit piece. Every peptide on this list works for someone. I just don't think most people are getting their money's worth. Take it as one peer's honest opinion and test things for yourself.

Hunter Williams answers your March 2026 submitted questions across six categories — GLP-1s, growth hormone secretagogues, healing & injury recovery, metabolic peptides, men's health, and autoimmune support.
Topics covered in this episode:
Tirzepatide at max dose (15mg) — what to do when you've plateaued and how to transition to retatrutide safely
Retatrutide side effects — nausea, gut shutdown, sensitivity after restarting, and dose adjustments
Stacking tirzepatide and retatrutide — why it's not dangerous and the strategic reason to combine them
Cagrilintide + tirzepatide for appetite suppression and A1C management
GLP-1 non-responders — why some people don't respond and what to use instead
Jardiance (SGLT2) alongside retatrutide — red blood cell considerations and cycling
Best peptide stacks for muscle building and body recomp on GLP-1s
Tesamorelin vs CJC-1295/Ipamorelin for belly fat and visceral fat reduction
HGH vs peptide secretagogues for women 55+ — longevity, muscle, and brain health
GH secretagogues for female athletes with RED-S and absent menstrual cycle
BPC-157 and anhedonia — dopamine effects and alternatives (TB-500, Cardilax, PEG-MGF, GHK)
Pre and post-op peptide protocols for faster surgical recovery
MOTS-c, methylation mutations (MTHFR/COMT), and why some people feel more fatigued
5-Amino-1MQ stacked with retatrutide — dosing caution and injectable vs oral
Methylene blue, 9-ME-BC, Adamax, and Semax as nootropics
Peptides for hypothalamus and pituitary repair after brain tumor removal
Selank, Noopept, and oxytocin for social anxiety and confidence
Thymosin Alpha-1 for autoimmune disorders like lupus
Post-prostatectomy libido restoration — testosterone, DHT, estradiol, and proviron
Urolithin-A and spermidine dosing for mitophagy and autophagy
Join the Axion Collective for live coaching calls every Thursday at 8PM Eastern. Submit your questions for next month's Q&A via the link in the description.

Website: ⁠⁠https://hunterwilliamshealth.com/⁠
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In this episode, I'm breaking down two peptides that I think are about to blow up: mazdutide and survodutide. Both are GLP-1 and glucagon dual agonists. Think of them like retatrutide minus the GIP component. And that glucagon piece is what makes them special.
I go through the trial data for both compounds. We're talking up to 21% weight loss with mazdutide and 80% liver fat reduction. Survodutide earned FDA breakthrough therapy designation for MASH based on a 62% resolution rate. These are serious numbers.
Here's what most people don't realize. These two peptides are NOT the same. Mazdutide runs close to a 50/50 split between GLP-1 and glucagon agonism. Survodutide is roughly 8 to 1 in favor of GLP-1. That changes everything about tolerability, appetite suppression, and how much metabolic burn you're actually getting.
I also cover practical use cases. Cycling off reta without losing momentum. Choosing between the two based on whether you need more appetite control or more energy expenditure. Dosing guidance for people just starting out. And why escalating too fast is still the number one mistake people make with GLP-1 peptides.

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Dr. Abid Husain is a triple board-certified cardiologist in cardiology, internal medicine, and functional medicine. After years in the traditional hospital system in New Jersey, he walked away to focus on what actually prevents disease — and now practices at the Boulder Longevity Institute, combining conventional medicine with peptides, HRT, and longevity protocols.
This is one of the most important conversations we've had on the podcast. If you're using hormones, peptides, or GLPs — or you're thinking about it — you need to hear what a real cardiologist has to say about all of it.
In this episode, Hunter and Dr. Abid cover why cholesterol alone is a terrible predictor of heart disease, what APOB and particle size actually tell you, and why the AI-powered cardiac imaging most people have never heard of is the real state of the art. They break down the testosterone and heart disease myth — fully debunked — along with hematocrit, blood clots, and what's actually dangerous on TRT. They cover the Women's Health Initiative, why bioidentical and synthetic hormones are not the same thing, and what women of any age need to know about HRT.
Then the conversation shifts to peptides — how BPC-157, TB-500, and Thymosin Alpha-1 benefit the cardiovascular system, what the SELECT trial proved about GLPs and heart health, why synthetic growth hormone and secretagogues are completely different, and how to think about cancer risk before starting GH protocols. They close with SS-31, Humanin, MOTS-C, and why the order you use mitochondrial peptides in actually matters — plus a deep dive into SGLT2 inhibitors, the most underrated longevity drug almost nobody in this space is talking about.
Episode 3 of The Hunter Williams Podcast.

https://hunterwilliamshealth.com/Podcast

───────────────────────────CONNECT WITH DR. ABID HUSAIN───────────────────────────📱 https://www.instagram.com/dr_abidhusain/🌐 https://boulderlongevity.com/▶️ https://www.youtube.com/@DoctorAbidHusain

───────────────────────────CONNECT WITH HUNTER WILLIAMS───────────────────────────🌐 https://hunterwilliamshealth.com/📱 https://www.instagram.com/hunterwilliamscoaching/
DISCLAIMERThis podcast is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare professional before starting any new health protocol.