Your Brain On

Drs. Ayesha and Dean Sherzai
Your Brain On
Latest episode

60 episodes

  • Your Brain On

    Your Brain On... Cheese

    14/01/2026 | 43 mins.
    Around the start of 2026, a study sparked viral headlines claiming that cheese could reduce dementia risk.
    But... nutrition science almost never works like this. One study can't "prove" a food is protective or harmful, and viral health claims often miss the most important details of research: how the data was gathered, what was actually measured, what variables were controlled for, and what it means in real life.
    In this episode, we unpack what the 'viral cheese study' (PMID: 41406402) actually found, what it DOESN'T mean, and why critical thinking around nutrition headlines matters more than ever.
    We discuss:
    • Why viral food headlines are so persuasive (and so often misleading)
    • What the cheese study REALLY reported
    • The difference between correlation and causation in nutrition research
    • Why long-term dietary recall data can be unreliable
    • How bias (including our personal food preferences) shapes interpretation of research
    • What "show me the data" really means in a world of clickbait science
    • How to interpret food and brain health studies without falling into extremes
    We also speak to Emily Sonestedt, research group leader and associate professor at Lund University, and one of the authors of the viral study.
    "Your Brain On..." is hosted by neurologists, scientists, and public health advocates Drs. Ayesha and Dean Sherzai.
    SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/ 
    'Your Brain On... Cheese' • SEASON 6 • EPISODE 6
    ———
    LINKS
    The study, 'High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence From a 25-Year Prospective Cohort Study': https://pubmed.ncbi.nlm.nih.gov/41406402/ 
    ———
    FOLLOW US
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    More info and episodes: TheBrainDocs.com/Podcast
  • Your Brain On

    Your Brain On... Chemotherapy

    04/12/2025 | 42 mins.
    Chemotherapy saves lives. But for millions, it also comes with side effects of cognitive fog, memory lapses, slowed thinking, and emotional flattening.
    In the past, 'chemo brain' has sometimes been dismissed as anecdotal. But, as science has evolved, we've come to understand the very real shifts in attention, memory, processing speed, and emotional regulation underpinning the impairment.
    In this episode, we break down what's happening in the brain during treatment, why these changes arise, and how healthier lifestyle choices can support our recovery.
    In this episode, we explore:
    • What 'chemo brain' really is (and why chemotherapy itself isn't the only thing contributing to it)
    • How inflammation, hormonal shifts, anesthesia, sleep disruption, and chronic stress impact cognition during cancer
    • The latest research on structural and functional brain changes during treatment
    • Why many cognitive effects are temporary (and how neuroplasticity supports recovery)
    • How cognitive fog intersects with identity loss and grief
    • The role of nutrition in supporting clarity, energy, memory, and mood during chemotherapy
    • How to navigate food fears, misinformation, and "miracle cancer diets"
    • The importance of gentle movement, sleep consistency, and stress management
    • How patients can advocate for themselves (including tips on what to discuss with their care team)
    Bringing their perspectives and expertise to this episode are two wonderful guests:
    • DR. LIZ O'RIORDAN: retired breast surgeon, author, and three-time breast cancer survivor, whose personal and clinical experience offers a rare, deeply human insight into cancer-related cognitive change.
    • NICHOLE ANDREWS, RDN: oncology dietitian, educator, and advocate for evidence-based, fear-free nutrition during and after cancer treatment.
    "Your Brain On..." is hosted by neurologists, scientists, and public health advocates Drs. Ayesha and Dean Sherzai.
    SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/ 
    'Your Brain On... Parkinson's' • SEASON 6 • EPISODE 5
    ———
    LINKS
    Dr. Liz O'Riordan:
    Website: https://liz.oriordan.co.uk/ 
    Instagram: https://www.instagram.com/oriordanliz/ 
    YouTube: https://www.youtube.com/channel/UC_t0jGeR8M4vCPSb68itjRQ 
    Nichole Andrews, RDN:
    Website: https://theoncologydietitian.com/ 
    Instagram: https://www.instagram.com/oncology.nutrition.rd/ 
    ———
    FOLLOW US
    Join NEURO World: https://neuro.world/ 
    Instagram: https://www.instagram.com/thebraindocs 
    YouTube: https://www.youtube.com/thebraindocs 
    More info and episodes: TheBrainDocs.com/Podcast
  • Your Brain On

    Your Brain On... Parkinson's (2025)

    26/11/2025 | 1h 16 mins.
    From 18th century London to the promise of a global cure: the 200-year history of Parkinson's disease.
    To mark the release of our 'Ask the MD' conversation with The Michael J. Fox Foundation for Parkinson's Research, and to welcome a new influx of listeners, we're sharing one of our very first episodes, first aired in August 2024.
    Watch our full 'Ask the MD' interview, focused on lifestyle strategies for boosting brain health, on the foundation's website: https://www.michaeljfox.org/news/lifestyle-strategies-boost-brain-health-ask-md-video 
    Parkinson's, a neurodegenerative disorder most commonly characterized by tremors and other motor symptoms, is so complex, many medical professionals are starting to classify it as a group of diseases, rather than a single disease.
    In this episode, we explain those complexities, including:
    • The motor symptoms (e.g. cogwheel rigidity, bradykinesia) and non-motor symptoms (e.g. depression, sleep disorders)
    • How the industrial revolution may have brought about environmental factors which contribute to Parkinson's
    • The differences and similarities between Parkinson's and other neurodegenerative diseases, like Alzheimer's
    • How Parkinson's manifests in our brains
    • Why one nurse was able to detect Parkinson's through smell
    • The neurogenetics of Parkinson's, and the ethical quandaries of evolving genetic technology
    • Why lifestyle — nutrition, exercise, etc. — is so key to preventing and managing Parkinson's
    Joining us for this extensive conversation are three incredible guests:
    • Dr. Rachel Dolhun, Senior Vice President of Medical Communications at The Michael J. Fox Foundation for Parkinson's Research
    • Dr. Michael Okun, evolutionary biologist, movement disorders specialist, and Director of the Norman Fixel Institute for Neurological Diseases
    • Dr. Matthew Farrer, neurogenetics expert and Professor Of Neurology at the University of Florida
    'Your Brain On' is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai.
    SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/ 
    'Your Brain On... Parkinson's' • SEASON 6 • EPISODE 4 (SEASON 3 REUPLOAD)
    —————
    LINKS
    Dr. Rachel Dolhun:
    At the Michael J. Fox Foundation: https://www.michaeljfox.org/bio/rachel-dolhun-md-dipablm 
    'Ask the MD' series: https://www.michaeljfox.org/ask-md 
    The Michael J. Fox Foundation on YouTube: https://www.youtube.com/@michaeljfoxfoundation/videos 
    Dr. Michael Okun:
    At the University of Florida: https://neurology.ufl.edu/profile/okun-michael/ 
    The book 'Ending Parkinson's Disease': https://endingpd.org/ 
    The Norman Fixel Institute: https://fixel.ufhealth.org/
    Dr. Matthew Farrer:
    At the University of Florida: https://neurology.ufl.edu/profile/farrer-matthew/
    —————
    References:
    Bloem, B. R., Okun, M. S., & Klein, C. (2021). Parkinson's disease. The Lancet, 397(10291), 2284-2303.

    Morris, H. R., Spillantini, M. G., Sue, C. M., & Williams-Gray, C. H. (2024). The pathogenesis of Parkinson's disease. The Lancet, 403(10423), 293-304.

    Dorsey, E., Sherer, T., Okun, M. S., & Bloem, B. R. (2018). The emerging evidence of the Parkinson pandemic. Journal of Parkinson's disease, 8(s1), S3-S8.

    Dorsey, E. R., Okun, M. S., & Tanner, C. M. (2021). Bad Air and Parkinson Disease—The Fog May Be Lifting. JAMA neurology, 78(7), 793-795.

    Tsalenchuk, M., Gentleman, S. M., & Marzi, S. J. (2023). Linking environmental risk factors with epigenetic mechanisms in Parkinson's disease. npj Parkinson's Disease, 9(1), 123.

    Reynoso, A., Torricelli, R., Jacobs, B. M., Shi, J., Aslibekyan, S., Norcliffe‐Kaufmann, L., ... & Heilbron, K. (2024). Gene–Environment Interactions for Parkinson's Disease. Annals of Neurology, 95(4), 677-687.

    Golsorkhi, M., Sherzai, A., & Dashtipour, K. The Influence of Lifestyle on Parkinson's Disease Management. In Lifestyle Medicine, Fourth Edition (pp. 919-924). CRC Press.

    Sherzai, A. Z., Tagliati, M., Park, K., Pezeshkian, S., & Sherzai, D. (2016). Micronutrients and risk of Parkinson's disease: a systematic review. Gerontology and geriatric medicine, 2, 2333721416644286.

    —————
    FOLLOW US 
    Join NEURO 
    Instagram: @thebraindocs
    Website: TheBrainDocs.com
    More info and episodes: TheBrainDocs.com/Podcast
  • Your Brain On

    Your Brain On... Eating Meat

    05/11/2025 | 1h 58 mins.
    Carnivorous diets have been woven into our history for millennia, but, with nutrition science advancing at an unprecedented pace over the past century... do we really still need to be eating meat?
    We live in a time of rising chronic disease, new longevity research, and a growing awareness of how our food choices shape our brain and our planet.
    We're also constantly exposed to 'nutrition tribalism': social media communicators and influencers building identities (and livelihoods) around polarizing dietary debates.
    It's a lot to navigate. So, we're cutting straight to the data in this episode.
    Plus: we're pulling on the work and research we've done in many different communities to explore how going plant-based can be as much a cultural or logistical hurdle as a health-driven or ethics-based choice.
    In this episode, we discuss:
    Whether protein deficiency is a realistic concern

    Protein myths: plant vs. animal

    What the actual protein science says (and why most Americans already get more than enough)

    The role of saturated fat, fiber, and the microbiome

    Processed vs. unprocessed meat — what matters most

    How identity, culture, and family can make going plant-based challenging

    How cooking method changes risk (yes, barbecue lovers… we go there)

    Meat alternatives: healthful option or "ultra-processed trap"?

    Practical, non-judgmental guidance for plant-forward or omnivorous eaters

     To give this divisive matter the nuance it deserves, we welcome three of the most authoritative voices in this space:
    DR. CHRISTOPHER GARDNER: the Stanford nutrition scientist behind landmark diet trials (including DIETFITS).
    DR. ADRIAN CHAVEZ: a nutrition researcher, educator, and consultant, who previously joined us for 'Your Brain On... Supplements'.
    DR. MATTHEW NAGRA: a nutritionist and science communicator, who you might remember from 'Your Brain On... Protein'.
    This is... Your Brain On Eating Meat.
    SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/  
    'Your Brain On' is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai.
    'Your Brain On... Eating Meat' • SEASON 6 • EPISODE 3
    LINKS
    Dr. Christopher Gardner
    Dr. Christopher Gardner at Stanford: https://med.stanford.edu/profiles/christopher-gardner  
    Dr. Christopher Gardner on Instagram: https://www.instagram.com/cgardnerphd 
    Dr. Adrian Chavez 
    Dr. Adrian Chavez on Instagram: https://www.instagram.com/dr.adrian.chavez 
    Dr. Adrian Chavez's website: https://www.dradrianchavez.com/  
    Dr. Adrian Chavez's Podcast: https://www.thenutritionsciencepodcast.com/ 
    Dr. Matt Nagra
    Dr. Matt Nagra on Instagram: https://www.instagram.com/dr.matthewnagra 
    Dr. Matt Nagra's website: https://drmatthewnagra.com/
  • Your Brain On

    Your Brain On... Nutrition (with Dr. Walter Willett)

    29/10/2025 | 41 mins.
    Everyone eats. It's the one thing we all have in common. And yet, nutrition has become one of the most confusing, divisive, and misunderstood sciences in modern life.
    Low-fat. High-fat. Keto. Vegan. Paleo. Superfoods. For every study, there's a headline that seems to say the opposite.
    In this episode, we turn to one of the most trusted voices in nutrition research to cut through the noise: Dr. Walter Willett, MD, DrPH.
    Dr. Willett, Professor of Epidemiology and Nutrition at Harvard T.H. Chan School of Public Health, has spent more than four decades studying how what we eat affects our health, longevity, and brain function. His work has helped reshape dietary guidelines around the world, replacing fear and fads with clarity and evidence.
    Together, we unpack what the science really says about diet and the brain: how food choices shape inflammation, cognition, and long-term disease risk, and what practical lessons decades of data can teach us about eating for life and longevity.
    In this conversation, we discuss:
    • How nutrition became so confusing (and what the data actually shows)
    • Why the quality of fat matters more than the amount
    • How refined carbohydrates fuel inflammation, insulin resistance, and brain fog
    • The power of fiber and the microbiome for mood and memory
    • Why plant-based proteins come out ahead for health and sustainability
    • How global dietary guidelines are changing (and what's still misunderstood)
    • The intersection of nutrition, planetary health, and human wellbeing
    Dr. Walter Willett has authored over 2,000 scientific papers and several landmark books, including 'Eat, Drink, and Be Healthy'.
    This is... Your Brain On Nutrition.
    SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/ 
    'Your Brain On' is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai.
    'Your Brain On... Nutrition' • SEASON 6 • EPISODE 2
    LINKS
    Dr. Walter Willett at Harvard T.H. Chan School of Public Health: https://hsph.harvard.edu/profile/walter-c-willett/  
    Dr. Willett's book, 'Eat, Drink, and Be Healthy': https://www.goodreads.com/book/show/5579.Eat_Drink_and_Be_Healthy 
    FOLLOW US
    Join NEURO World: https://neuro.world/  
    Instagram: https://www.instagram.com/thebraindocs 
    YouTube: https://youtube.com/thebraindocs 
    Website: https://thebraindocs.com/

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About Your Brain On

A podcast about the neuroscience of everything. From neurologists, researchers, and public health advocates Drs. Ayesha and Dean Sherzai, explore every aspect of our world through a neuroscientific lens, with science-based stories, interviews, anecdotes, and brain health facts. Equip yourself with neurologically sound answers to life's everyday health questions and learn the essentials of brain health and optimization, one topic at a time.
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