Peptide of The Week

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

Welcome back, warriors! In this special Peptide of the Week episode, JD Denham and William T. Haas are joined by Dr. Scott Collie a long-time friend and hormone optimization expert to take a deep dive into blood work, testosterone replacement, ester differences, side effects, and proper protocol stacking.

This one’s all about optimizing hormones with real strategy. If you’re considering TRT or already on it, this is required listening.

Chapters: 
00:00 Welcome, New Studio & Guest Introduction
03:00 Why Blood Work Matters Before TRT
08:45 Estrogen, DHT & Detox Pathways Explained
15:30 Alternatives to TRT (Clomiphene & Creams)
17:00 What Testosterone Really Does in the Body
22:20 TRT Dosing: Replacement vs Overdoing It
28:00 Supplements & Peptides to Support TRT
31:00 Testosterone Esters Explained (Cyp, Prop, Sustanon)
41:00 Injection Frequency, PIP & Carrier Oils
49:00 Diet, Fasting & Training Adjustments
52:30 MOTS-C vs SS-31 (Mitochondria Explained)
56:00 Intramuscular vs Sub-Q Peptides
57:30 Testosterone Therapy for Women
1:00:00 Final Thoughts & Wrap-Up

We cover:
🩸 Blood Work & Baseline Panels
– Why a comprehensive panel is essential before starting TRT or peptide therapy
– Inflammation markers, homocysteine, iron levels & clotting risks
– Common doctor mistakes: running only total testosterone with no free test or estrogen panels
– Genetic factors (MTHFR), detox pathways & why gut health matters for estrogen clearance

💉 TRT Side Effects & How to Avoid Them
– Estrogen conversion, DHT, prostate health & hair loss explained
– Common side effects (acne, gyno, fatigue, mood swings) and how to minimize them
– Methylation support: B6, B12, methyl folate, DIM, calcium glucarate
– Natural blood thinners: fish oil, natto kinase, bergamot, turmeric

🧬 Ester Education – From Sipionate to Propionate to Sustanon
– Fast vs slow release esters explained
– When to choose Test Prop vs Sip vs Sustanon vs Enanthate vs Undecanoate
– Daily vs weekly dosing strategies & injection protocols (IM vs SubQ)
– What "PIP" (post-injection pain) means and how to reduce it (oil type, heating, MCT vs grapeseed)

🔥 Optimal TRT Dosing
– Why 200–250mg is often too much for long-term use
– Why 125–150mg/week is the true sweet spot for most men
– Expected results timeline: 3 weeks to feel it, 6 weeks to retest, 3 months to dial it in
– Monitoring lipid panels, hematocrit, ferritin, homocysteine over time

🧪 Stacking with Peptides
– Using TB-500 and BPC-157 for injury recovery (yes, even for teens)
– Thymosin Alpha-1 for immune support alongside TRT
– When to avoid stacking GH secretagogues or MK-677 in younger athletes
– Women & TRT: microdosing for libido, bone density, mood & anemia

💡 Bonus Topics
– Intramuscular vs SubQ injection effectiveness
– Mitochondrial repair: Why SS-31 should come before MOTS-C
– Why some people feel NAD or MOTS-C — and others don’t (and why that’s okay)

📌 Bottom line: Hormone optimization isn't about blasting your body. It's about strategy, testing, and long-term health. From esters to estrogens, this episode cuts through the fluff with real talk and proven science.

🧪 This isn’t hype it’s hard data, real-world feedback, and first-hand experience.

💬 Got questions or peptide topics you want broken down? Drop a comment below.

📺 Subscribe for more no-fluff, real science weekly.

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

Welcome back, warriors. In this week’s Peptide Q&A, JD Denham and William T. Haas break down a massive lineup of real-world questions covering everything from top peptide rankings and injury healing to fat loss for already-lean women, mitochondrial health, autoimmune conditions, and how to actually vet peptide vendors without getting burned. No rehearsed answers. Just experience, debate, and straight talk.

We cover:

🔥 Top 5 Peptides Explained: JD and Will rank their personal top peptides from the Wolverine stack and RETA to AOD-9604, HGH, IGF-1 LR3, MOTS-C, and NAD with real reasons behind each choice
🧬 Switching Tesa/IPA to CJC/IPA: Why it’s okay to rotate secretagogues, how long to run each, and realistic dosing ranges for men vs women
🏗️ IGF-1 LR3 Dosing & Cycling: How to properly titrate, why cycles should stay short (4–6 weeks), and what “too much” actually looks like
🧪 Peptide Vendor Red Flags: COAs, missing endotoxin testing, reconstituted peptides, fake lab reports, and why “cheap” peptides are usually cheap for a reason
⚠️ Endotoxins Explained: What acceptable levels really are, why most vendors don’t test for them, and how much risk actually exists in the real world
🔥 Rapid Fat Loss & Liver Enzymes: Why fast weight loss can temporarily elevate ALT/AST, how GLP use plays into it, and why the liver usually rebounds
💪 Fat Loss for Lean Women: Why RETA may not be ideal for already-lean females, better options like AOD + Tesamorelin, and when eating more fixes stalls
⚡ Mitochondrial Stack Strategy: MOTS-C vs SS-31 whether to run together, timing logic, dosing ranges, and why consistency matters more than sequencing
🦴 Severe Tendonitis & Injury Healing: Wolverine stack dosing strategies, loading phases vs long cycles, injection placement, and when to go aggressive
🧠 Bulging Discs & Back Pain: Why peptides help inflammation but won’t fix structural disc issues and when surgery is the real solution
🧑‍⚕️ Vitiligo & Autoimmune Support: Peptides that may help skin pigmentation and immune balance including BPC-157, GHK-Cu, KPV, Melanotan-1, and Thymosin Alpha-1
💉 Glow Blend + Wolverine Together: How to stack BPC, TB-500, and GHK-Cu safely, daily vs weekly dosing, and copper limits
😴 Sleep, Recovery & Budget Picks: Best one-to-two peptide choices when money is tight and long-term recovery matters

💡 Peptides aren’t magic but when dosing, sourcing, nutrition, and training line up, they’re powerful tools.

👉 Drop your questions for the next Q&A.

📌 Subscribe for weekly Q&As, deep dives, and real-world protocol breakdowns.

You’re a warrior. Act like one.

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

Welcome back, warriors! In this powerhouse episode of Peptide of the Week, JD Denham and William T. Haas break down two of the most talked-about compounds in the game: AOD-9604, the fat-blasting fragment of HGH, and IGF-1 LR3, the muscle-building giant.

From deep dives into dosing and cycling to real-world protocols, stacks, and who should be taking what—this episode is packed with expert insight, personal anecdotes, and no-BS education for anyone trying to lose fat or build lean mass.

We cover:

🔥 AOD-9604 Breakdown
– A synthetic fragment of HGH (amino acids 177–191) that’s purely fat-burning
– No effect on IGF-1, insulin sensitivity, or muscle mass = ultra-targeted shredder
– Great for men and women, especially those coming off GLP-1s like Retatrutide
– Best stacked with: Retatrutide, SLU, 5-Amino-1MQ, or L-Carnitine
– Typical dose: 250–500mcg, 1–2x/day
– Cycle: 12–16 weeks, then rotate to another fat burner

💪 IGF-1 LR3 Deep Dive
– Long-acting form of IGF-1 (stays active for 20–30 hours)
– Directly signals lean muscle growth, nutrient partitioning, and recovery
– Bypasses pituitary, HGH, and liver—delivers pure muscle-building power
– Works best when paired with heavy training volume and carbs (not for keto)
– Use post-workout, pre-big meals, or pre-workout for massive pumps
– Dose: Start at 20mcg/day, ramp to 60–80mcg max. Run for 4–6 weeks max
– Expect: Fuller muscles, faster recovery, and nutrient super-absorption

🧪 Stacking Strategies for Fat Loss & Muscle Growth
– Best Cutting Stack (Men/Women): Retatrutide + AOD + SLU + L-Carnitine
– Best Muscle Growth Stack: TRT + IGF-1 LR3 + Protein + Carbs + Volume Training
– Maintenance/Transition: Swap from GLP-1 to AOD for ongoing fat metabolism
– Advanced Users: Add Tesamorelin, MK-677, or GH Secretagogues depending on goals
– Cycle Recommendation: AOD (16 weeks), IGF-1 LR3 (4–6 weeks), then rotate

💡 Tips & Warnings
– IGF-1 LR3 requires high protein intake + carbs to be effective
– Not ideal on a strict keto or fasting protocol
– AOD is not stimulatory, very safe, and can be used long term
– Do not inject AOD if it gels—reconstitute with proper AOD water or acetic solution
– Avoid stacking GLP-1s together, but you can stack everything else

🧠 Big Takeaways
– Peptides are optimizers, not miracle workers
– Fat burners only shine when paired with workouts and clean eating
– IGF-1 LR3 = closest peptide to a steroid effect, but safer and leaner
– If you're looking to shred fat or pack on lean muscle, these two are top-tier

Chapters
00:00 Intro
00:18 Hat mix-up + sick talk
04:02 Episode topic: HGH family peptides overview
05:20 AOD-9604 explained (fat loss only)
11:06 HGH vs Secretagogues vs IGF-1 (key differences)
18:40 HGH timing + safety/cancer talk
25:19 AOD dosing + how long to run it
28:02 AOD mixing/gelling problem + fix
34:49 IGF-1 LR3 explained (muscle growth peptide)
38:10 Best ways to use IGF-1 (post-workout / carbs / cheat meal)
46:11 IGF-1 dosing basics + final recommendations
49:09 Outro

⚔️ Drop your questions in the comments. JD and Will read every DM.

🎥 Subscribe for more real-talk, no-hype breakdowns. Q&A episode drops later this week.

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

Welcome back, warriors! In this week’s Peptide Q&A, JD Denham and William T. Haas dive into another real-world round of questions from mixing protocols and fat loss stacks to bulking strategies, side effects, and safety-first decisions. No theory. Just what they’ve seen, tested, and learned the hard way.

We cover:

💉 Mixing Multiple Peptides in One Shot: How JD combines multiple peptides into one sterile vial to avoid 5 separate jabs and why glutathione should stay separate
🧪 Cloudy Syringe Warning Sign: What it means when a mix turns cloudy and when that’s your sign to stop combining certain compounds
🧠 pH Balance Debate: JD shares what a trusted source in the peptide world told him about mixing and why he doesn’t stress the “internet experts”
🍽️ Bulking on RETA + AOD: Can you gain muscle while using fat-loss peptides? Yes but only if you’re eating in a true surplus
🔥 RETA Killing Appetite While Bulking: How to push calories even when you’re full fast and why “eat past full” becomes the real skill
⚙️ Osteoporosis Stack for Mom: Tesamorelin + Ipamorelin dosing for older women, why lower doses matter, and why bedtime shots amplify results
🧬 Adding HGH for Bone Health: Why JD likes low-dose HGH for anyone over 40, and how it stacks alongside Tessa/IPA
👕 Warrior Makers Tank Tops: What’s coming soon, why the last cutoffs were way too long, and what brands they actually like
🚫 Benign Tumor + Peptides: Why both JD and Will say to cut peptides completely when tumor growth is involved even “health boosting” ones like NAD and MOTS-C
🔥 CJC/IPA or Tessa/IPA + AOD Together: Why these stack clean with zero overlap, and why AOD stays one of JD’s top fat burners
📩 Provider Questions: How to DM Warrior Makers or JD Fit to get pointed in the right direction
🟥 Red Welts from MOTS-C + GHK-Cu: Why it might be an allergic reaction, injection depth issues, or sensitivity plus KPV/antihistamine suggestions
🥵 GHK-Cu Sting Fix: The “no sting water” solution that makes GHK-Cu tolerable (and what to realistically expect)
❄️ Should You Freeze RETA? Hard no why cold + dry + dark storage wins, and why freezing isn’t the move for home use
🏋️ Best Peptides for Bulking: IGF-1 LR3 post-workout, MK-677 for hunger, and the truth: peptides don’t replace food
📏 IU vs Units Confusion: Why “20 IU” isn’t the same thing as “20 units,” and why water volume changes everything
🔥 How Long to Run AOD: Why JD runs it long-term, and why Will suggests cycling off if the body adapts
💓 Increased Heart Rate on Tessa/IPA:** Water retention, blood pressure, and why titrating up slowly is the smartest way to restart
🧠 Anti-Aging Stack for Overstimulated Women:** Low-dose NAD, GHK-Cu, and low-dose HGH keeping results without overstimulation

👉 Drop your peptide questions below for next week’s Q&A.

📌 Subscribe for weekly protocols, education, and no-BS real-world answers.

You’re a warrior. Act like one.

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas break down one of the most exciting performance enhancers in the peptide-adjacent world SLU-PP-332. It’s not technically a peptide, but it gets lumped in for a reason.

From fat metabolism to increased cardio endurance to insane nutrient partitioning this compound mimics exercise at the cellular level. Whether you're an elite athlete or just trying to drop fat and feel better, this one's worth a look.

We cover:

🔥 What is SLU-PP-332?
– Classified as an exercise mimetic your muscles behave as if you're training, even at rest
– Increases endurance and fat oxidation while preserving glucose stores
– Revs up the mitochondria your cells’ power plants to generate clean energy
– Works within 4–6 hours of dosing, ideal for 2–3x daily use
– Comes in injectable, oral, and sublingual forms (we’ve tried them all)

💊 Forms & Favorite Dosing Protocols
– Sublingual: ideal for daily use (1mg 3x/day = sweet spot for most gym-goers)
– Injectable: JD and Will both prefer this form for higher-dose benefits
– Study-based doses range from 250mcg/day to experimental 50mg/day protocols
– Current consensus: 1–2mg 2–3x/day = powerful and sustainable
– JD’s protocol: sublingual at desk AM/midday/PM Will’s dose: 2mg injectable pre-work

⚙️ Stacking Benefits & Combos
– Fat Loss: Sloop + AOD-9604 + Retatrutide + Tesamorelin
– Endurance/Performance: Sloop + L-Carnitine + Mots-C + DSIP for recovery
– Gut & Recovery: Stack with KPV, BPC-157, TB-500 + GHK-Cu (aka the Wolverine stack)
– Energy + Mitochondria Health: Add NAD or Mots-C for deep mitochondrial support
– For women or entry-level users: sublingual is a great, safe gateway protocol

🧠 What It’s NOT
– Not a stimulant. No heart rate spike, no crash, no adrenal stress
– Works by enhancing energy efficiency, not by jacking up your system like clenbuterol
– Allows for fat burning during rest or sleep without harming recovery or muscle tissue

⚠️ Notes on Sloop + BAM Mix
– Popular hybrid: 250mcg Sloop + 50mg BAM burns fat via dual mitochondrial mechanisms
– JD recommends adding 1000mcg more Sloop if using combo products for enhanced burn
– Not WADA-approved athletes should check clearance

📆 Protocol Summary:
– Beginner dose: 250–500mcg 3x/day
– Advanced use: 1–2mg 2–3x/day (injectable or sublingual)
– Cycle: Run 6–12 weeks, then rotate or stack with Mots-C or NAD
– Perfect stack (JD’s pick): AOD AM, Sloop 3x/day, Retatrutide 3x/week, Tesamorelin PM, DSIP for sleep
– Will’s pick: Testosterone base + Ipamorelin/CJC + Sloop + Wolverine stack (BPC + TB + GHK-Cu)

💬 Curious about mixing this with your current peptide plan? Drop questions in the comments we read every single one.

📺 Subscribe now next episode is the Q&A drop, and you don’t want to miss it.