Peptide of The Week

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover building muscle at 13.5% body fat, running carnivore diet on "R", St. John's Wort interactions, peptides for a marathon at 53, the mitochondrial stack sequenced properly, and whether IGF-1 LR3 and HGH can be run together.

Chapters:
00:00 – Intro & Holiday Weekend Recap
00:39 – Shark Stories & Ocean Safety Talk
07:35 – School, Coaching & Warrior Maker Updates
08:18 – Q&A: Muscle Gain & a Shredded Stomach (Age 43)
15:11 – Q&A: R & Fat Digestion on Carnivore
20:59 – Q&A: St. John's Wort & Peptide Interactions
24:39 – Q&A: KPV for Connective Tissue Disease
27:42 – Q&A: Low Energy on Tirzepatide & AOD (Age 38)
36:05 – Q&A: How Long Do Unmixed Peptides Last?
38:36 – Q&A: Do Peptides Show Up on Drug Tests?
40:35 – Q&A: Stacking HGH, CJC/Ipa & IGF-1 LR3
47:36 – Q&A: Marathon Training Stack After Major Weight Loss
51:40 – Q&A: Sequencing Mitochondrial Peptides for Energy (Age 55)
56:53 – Outro & New Hyperbaric Chamber Announcement

We cover:
• Building Muscle at 13.5% Body Fat as a Woman: Why eating more not less is the answer, why AOD should come out, and why 5-Amino-1-MQ, SLU-PP-332, and Tesamorelin-Ipa are the right additions

• Carnivore Diet on "R" with Ulcerative Colitis: Why high fat plus slow gastric emptying causes the problem, why small frequent meals fix it, and why a little fiber and 50 grams of carbs around training goes a long way

• St. John's Wort & "R" Interactions: Why R is broken down by protein enzymes not the liver's CYP450 system, why St. John's Wort is notorious for drug interactions, and why milk thistle, TUDCA, and glutathione are better liver support

• Mixed Connective Tissue Disease & KPV: Why oral BPC and KPV are generally safe to add, and why coming off a biologic requires a knowledgeable doctor not a podcast

• Low Energy on Tirzepatide at 133 Pounds: Why under-eating protein is the most likely culprit, why tracking macros is more powerful than any peptide, and why NAD, SS-31, MOTS-C, and methylated B12 are the right energy stack

• Lyophilized Peptide Shelf Life The Real Answer: Why unmixed peptides last up to two years in a cool dark place, why freezing creates moisture risk, and why the crisper drawer in a small fridge is all you need

• Do Peptides Show Up on a 5-Panel Drug Test: Why no standard workplace panel tests for peptides and why only high-level professional sports testing would even attempt it

• HGH vs IGF-1 LR3 — Can You Stack Both: Why CJC-Ipa is redundant once you're on HGH, when combining HGH and IGF-1 LR3 adds benefit vs. risk, and why MK-677 may be the smarter muscle-building add-on

• Marathon Prep Stack at 53 Down 87 Pounds: Why Wolverine is non-negotiable at this age and mileage, why Cardarine and SLU-PP-332 are the endurance game changers, and why adding HGH now gives it time to work before December

• Mitochondrial Stack for a 55-Year-Old Working at 2:30 AM: Why SS-31 comes first for at least two weeks, when to layer in MOTS-C, why NAD timing doesn't matter, and why Dihexa, magnesium glycinate, and glycine round out the protocol

You're a warrior. Act like one.

Follow us on social media:
JD's Instagram: https://www.instagram.com/jddenhamofficial/
Will's Instagram: https://www.instagram.com/williamthaas/

Join The Community: https://www.skool.com/peptideresearchinstitute/about

Peptide Of The Week Website: https://peptideoftheweekpod.com

Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas get back to basics and break down two compounds people have been asking about. ARA-290 for nerve pain and neuropathy, and 5-Amino-1MQ for fat burning and metabolic optimization. Two very different compounds with very different objectives.

Chapters:
00:00 – Intro & Show Plugs
02:37 – New Podcast Format Announcement
03:28 – ARA-290: Redefining Nerve Pain & Repair
05:09 – Nerve Injury Stories: Sciatica & Back Surgery
08:03 – How ARA-290 Works: Macrophage Reprogramming
13:15 – Dosing Protocols & Cost
15:47 – Nerve Pain, Surgery & Long-Term Nerve Damage
17:39 – Tips: Timing, Sleep, Nutrition & Exercise
22:23 – Side Effects, Safety & What to Stack With
24:59 – Compound #2: 5-Amino-1MQ for Fat Burning
27:32 – Real User Results & Fat Loss Data
30:00 – Dosing: Oral vs. Injectable & Cycle Length
33:16 – Zone 2 Cardio & Maximizing Fat Burn
37:37 – Stacking with GLP-1s & Breaking Plateaus
40:49 – Outro, Feedback & Next Episode Preview

We cover:
🧠 ARA-290 — Nerve Repair and Neuropathic Pain
– First discovered and researched in the early 2000s, still experimental but with human trials
– Selectively binds to the Tissue Protective Receptor (TPR) on immune cells, nerve cells, and metabolic tissues
– Reprograms macrophages from pro-inflammatory to anti-inflammatory, actually healing the nerve instead of masking pain
– Used for small fiber neuropathy, sarcoidosis, autoimmune nerve conditions, diabetic neuropathy, and post-viral recovery including long COVID
– Unlike painkillers, effects continue AFTER you stop taking it because it is healing the nerve, not just covering the pain

Real-world reports:
– Burning pain dropped from a 7 out of 10 to a 2 out of 10 within 3 weeks in diabetic neuropathy patients
– Mood lift and mental calm reported within 4 days (not the main intention but consistently reported)
– Nerve fiber density measurably increases over days to weeks
– Effects often persist 3 to 6 months post-cycle

What to stack with:
– BPC-157 and TB-500, NAD+, alpha lipoic acid, methylcobalamin, and B vitamins

What to avoid:
– NSAIDs and corticosteroids will blunt the effects
– Alcohol, high sugar, ultra-processed food, and chronic sleep deprivation all work against nerve healing

🔥 5-Amino-1MQ — The Fat Burning Compound
– Not a peptide, technically a small molecule compound. First developed around 2014
– Blocks NNMT (Nicotinamide N-Methyltransferase), which is massively upregulated in obese fat tissue and actively drives fat storage
– Blocking NNMT shifts your metabolism to burn fat instead of store it, essentially injecting keto without the diet
– Also replenishes NAD+ levels that have been depleted with age
– In animal studies: obese mice lost 7 to 9% of fat with no loss of lean muscle while eating the same amount of food
– Adds an additional 7 to 9% fat loss on top of GLP-1 results because it works on a completely different pathway

Who it is for:
– Anyone on a GLP-1 who has plateaued, this will relight the fire
– People with insulin resistance or pre-diabetes, it increases insulin sensitivity
– Already lean people looking to get even leaner and enhance body composition
– People with metabolic syndrome or NAD+ depletion

Best stacks: GLP-1 (especially R), MOTS-C, NMN, NAD+, L-Carnitine, Alpha Lipoic Acid, CoQ10

Follow us on social media:
JD's Instagram: https://www.instagram.com/jddenhamofficial/
Will's Instagram: https://www.instagram.com/williamthaas/

Peptide Of The Week Website: https://peptideoftheweekpod.com/

Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Join The Community: https://www.skool.com/peptideoftheweekcommunity

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover managing high hematocrit on TRT, why HDL drops on testosterone, navigating peptide social media censorship, peptide dosing math broken down simply, hair loss and DHT blockers, and protocols for insulin resistance and PCOS.

Chapters:
00:00 – Intro & School Platform Update
01:20 – Coaching Program Update & New Coaches
03:48 – Website Launch & Losing Social Media Channels
04:40 – Personal Life & Family Updates
07:13 – Upcoming Hawaii Trip
08:52 – Teaching Discipline: The Jax Story
12:23 – Q&A: Managing High Hematocrit on TRT
21:33 – Q&A: Insulin Resistance & Weight Loss
28:24 – Q&A: Peptide Dosing Math Explained
36:41 – Q&A: Navigating Social Media & Regulation
44:29 – Q&A: Low HDL on TRT
49:06 – Q&A: Adjusting Your Stack After Reaching Goal Weight
58:35 – Q&A: Hair Loss & DHT Blockers on TRT
1:07:24 – Q&A: Microplastics in Backwater Vials
1:10:14 – Q&A: PCOS, ACL Recovery & Building Muscle & Outro

We cover:
• High Hematocrit & Thick Blood on TRT: Why testosterone shuts off your body's governor on red blood cell production, why dehydration skews the reading, and why donating blood twice a year is the single best fix
• Insulin Resistance & Slow Fat Loss in Women: Why cardio is making it worse, why 40 grams of protein right when you wake up matters, and why walking 10 minutes after every meal may do more than any peptide
• Peptide Dosing Math Explained Simply: A live walkthrough of how to calculate exact milligrams per unit for GHK-CU, KPV, MOTS-C, C-Max, and "R" so nothing gets wasted
• Navigating Social Media Censorship as a Peptide Educator: Why JD's YouTube got pulled for a 10-minute fasting post, why algorithms are replacing human judgment, and why School and owned platforms are the only safe play
• Going Down on "R" After Reaching Goal Weight: Why 5 migs every two weeks makes no sense given the half-life, why 2-3x weekly dosing works better, and when to swap Tesamorelin for 2 IU of HGH
• Low HDL on TRT — What Actually Helps: Why niacin has been proven not to work, why aromatase inhibitors make it worse, and why mono-unsaturated fats and fasting are the real levers
• Hair Loss, DHT, Finasteride & Dutasteride: Why you're going to lose your hair if your family did regardless, why DHT blockers tank libido and mood, and Will's strategy of microdosing for 3 days to reset without the side effects
• Plastic vs. Glass Bacteriostatic Water Vials: Why benzyl alcohol pulls microplastics from plastic vials over time and why glass is the cleaner long-term choice
• 32-Year-Old Female with PCOS & ACL Tear: Why Tesamorelin-Ipa blend is the right starting point, why "R" at 500 mcg is virtually nothing, and why protein immediately after waking is non-negotiable

📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results.

You're a warrior. Act like one.

Follow us on social media:
JD's Instagram: https://www.instagram.com/jddenhamofficial/
Will's Instagram: https://www.instagram.com/williamthaas/

Join The Community: https://www.skool.com/peptideresearchinstitute/about

Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas sit down with Dani Carroll, a holistic health coach with 17 years of experience, Ayurvedic specialist, and yoga teacher. This one is not about peptides. It is about the thing most of us completely overlook that could be undermining everything else we do. Water.

Chapters:
00:00 – Intro & Meeting Dani Carroll
01:05 – Dani's Autoimmune Story & Failed Treatments
07:00 – Discovering the Water That Changed Everything
11:11 – First Results: Brain Fog, Joint Pain & Skin
13:00 – Testing It on Her Skeptical Parents
17:56 – Why Isn't Anyone Talking About Water?
19:17 – The Truth About Tap & Bottled Water
25:44 – How Bottled Water Degrades in Transit
27:47 – RO & Distilled Water: The Mineral Problem
29:46 – Understanding pH & the Alkaline Water Scam
34:06 – JD's GERD & Gut Health Case Study
41:19 – Chlorine, Showers & Skin Absorption
50:04 – How the Machine's Settings & Hydrogen Water Work
1:14:04 – Checking Your Own Tap Water (EWG Database)
1:21:13 – Five Rules for Drinking Water & Outro

We cover:
💧 Dani's story
– Autoimmune disease surfaced at 16, misdiagnosed with rheumatoid arthritis, full body joint pain and monthly skin peeling episodes
– Spent years going through every elimination diet, raw vegan, autoimmune paleo, nothing lasted beyond 90 days
– Gut microbiome destroyed by antibiotics prescribed by doctors who never addressed the root cause
– Discovered structured alkaline water during postpartum depression, within 45 days her skin stopped peeling for the first time in years
– 90 days in she was glowing. Her father lost weight, eliminated gout, and cleared acid reflux within months

🧬 Why water matters more than food
– You can survive 40 days without food. You die in 3 days without water. Yet nobody talks about water quality
– Tap water contains chlorine, fluoride, heavy metals, pharmaceuticals, forever chemicals, pesticides, and herbicides
– The chemicals in tap water are often added to protect aging city pipes, not to clean your water
– Water softeners add salt or potassium to protect your pipes, they are not designed to be consumed
– RO filtered water strips all minerals. Drinking it long term leaches minerals from your bones, causing bone density loss and eventually osteoporosis
– Plastic bottled water is dead water that sits in your stomach, does not absorb properly, and leaches microplastics

🚿 Your shower is a bigger problem than you think
– You absorb approximately one liter of water through your skin during a 10 to 15 minute hot shower
– Pores open in hot water, you inhale chlorine vapor, and your body absorbs it all

The 7 pH settings explained:
– 2.5 pH (hypochlorous acid): kills E. coli, MRSA, and bacteria. Use to sanitize meat, surfaces, and as mouthwash
– 11.5 pH (strong alkaline): veggie wash, makeup remover, skin treatment, poison ivy compress, eczema protocol. Neutralizes pesticides and herbicides which are designed to be water resistant
– 6.0 pH (beauty water): matches your skin and hair pH of 6.4. Use to wash your face and hair, works as a leave-in conditioner without stripping natural oils
– 7.0 pH (neutral): neutral rinse water for cooking and final food rinse
– 8.5, 9.0, 9.5 pH: drinking water levels depending on your health goals and tolerance

Follow us on social media:
JD's Instagram: https://www.instagram.com/jddenhamofficial/
Will's Instagram: https://www.instagram.com/williamthaas/
Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Follow Dani Carroll:
Instagram: https://www.instagram.com/rawsomeyoga/
TikTok: https://www.tiktok.com/@rawsomeyoga

Join The Community: https://www.skool.com/peptideoftheweekcommunity

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover why SS-31 has been a game changer for JD, how to properly sequence the mitochondrial stack, NAD reactions and replacements, when to come off R, building muscle at 12% body fat, fertility protocols while on TRT, and whether you really need to plan your protocols a year in advance.

Chapters:
00:00 – Intro & Personal Health Updates
03:06 – SS-31 & Finding the Right Protocol
06:04 – Disneyland Trip & Kids' Sports Talk
13:48 – Warrior Makers Coaching Program Launch
18:37 – School Platform Updates & Podcast Feedback
21:58 – Q&A: Sleep, Hormones & Energy for a Busy Mum
34:15 – Q&A: Major Weight Loss & a Bad NAD Reaction
39:07 – Q&A: Peptide Storage & Condensation
41:50 – Q&A: SS-31, MOTS-C & NAD Sequencing
49:31 – Q&A: Coming Off Retatrutide's Maintenance Dose
55:22 – Q&A: TRT & Fertility Protocols
1:08:14 – Q&A: Gut Health Flare-Up & Peptide Pause
1:14:53 – Q&A: Runner Wanting Muscle Over Fat Loss
1:21:14 – Q&A: Building a Smart Annual Peptide Plan
1:29:13 – Outro & Coaching Call Details

We cover:
• Why JD Is Feeling the Best He Has in Years: Why higher-dose SS-31 gets the credit, why less compounds often means feeling better, and why starting with two compounds and adding slowly is the smarter approach
• NAD Allergy What to Do Instead: Why reactions to NAD may come from the compound itself not just contamination, why SS-31 at five-plus megs is the closest alternative, and why blood work and hormone optimization should come first at 35
• Peptide Storage and Condensation on Vials: Why condensation on the outside of a vial does not mean moisture got inside, and why a dedicated mini fridge beats any canister solution
• Mitochondrial Stack SS-31, MOTS-C and NAD Sequenced Properly: Why SS-31 plugs the holes before MOTS-C revs the engine, why quarterly month-long SS-31 cycles make sense, and why NAD can run anytime regardless
• 42-Year-Old Australian Female Should You Come Off R: Why she probably doesn't need it at all, why 5-Amino-1-MQ and SLU-PP-332 are the right replacements, and why discipline is a better long-term tool than any GLP
• Fertility Protocol at 33 While Trying for a Baby: Why TRT doesn't have to stop, why HCG and Kisspeptin together improve fertility odds, and why Enclomiphene is the smarter choice over standard Clomid
• Building Muscle at 12% Body Fat and Running 60-70 Miles a Week: Why all that running is burning off the muscle she's trying to build, why cutting back to HIIT and lifting heavy is the real answer, and why low-dose testosterone may matter more than any IGF-1
• Total T of 420 at 43 Is It Time for TRT: Why 420 with low energy is answer enough, why TRT will change his life, and why planning protocols a full year out is overrated for most people
• How to Build a Smart Annual Protocol Without Overcomplicating It: Why JD and Will plan four months at a time, why trying too many compounds at once tells you nothing, and why the gateway compounds R and BPC are always the right starting point

📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results.

You're a warrior. Act like one.

Follow us on social media:
JD's Instagram: https://www.instagram.com/jddenhamofficial/
Will's Instagram: https://www.instagram.com/williamthaas/

Join The Community: https://www.skool.com/peptideresearchinstitute/about

Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/